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Relationship between interlukine-1 alpha and polyamines levels in serum and saliva as potential biomarkers in the diagnosis of oral squamous cell carcinoma
المؤلفون المشاركون
Gaphor, Shanaz M.
al-Talabani, Nizar G.
Hamad, Abd al W. R.
المصدر
Journal of Baghdad College of Dentistry
العدد
المجلد 22، العدد 1 (31 مارس/آذار 2010)، ص ص. 50-54، 5ص.
الناشر
تاريخ النشر
2010-03-31
دولة النشر
العراق
عدد الصفحات
5
التخصصات الرئيسية
الموضوعات
الملخص EN
Back ground: Oral cancer is one of the prevalent cancers of the body and is one of the 10 most common causes of death.
Oral squamous cell carcinoma (OSCC) accounts for over 90% of these tumors.
The aim of this study was designed to detect biochemical markers in serum and saliva of oral squamous cell carcinoma patients and to evaluate their validity in monitoring and diagnosis and to correlate relationship between IL-1 alpha and polyamines.
Patients and Methods : the level of polyamines in the serum and saliva of (30) patients with OSCC and (20) healthy individuals as control group was measured.
Level of proinflammatory cytokine Interleukin 1α (IL-1α) was detected by enzyme linked immunosorbent assay (ELISA).
Polyamines (spermidine and spermine) were determined by high performance liquid chromatography (HPLC) in both serum and saliva of patients with OSCC and control group.
Results and Discussion : salivary IL-1 alpha was useful in the diagnosis of OSCC patients.
The total serum and salivary polyamines level of OSCC were significantly higher than the control group (P < 0.001).
Both salivary and serum polyamines level were reliably accurate test in separating between OSCC patients and control group.
There was significant difference in salivary spermine level among OSCC patients in relation to lesion status.
Spermine levels were reduced in recurrent lesion especially with metastases.
There were significant differences in serum polyamines level among OSCC patients in relation to duration of the disease (P < 0.05).
Conclusion: There was a significant weak correlation between salivary IL-1α and salivary spermine (r = 0.377) (p < 0.05).
From the results of the presents study, it can be concluded that detection of polyamines in serum and saliva are useful and valuable diagnostic markers in diagnosis and early detection of OSCC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gaphor, Shanaz M.& al-Talabani, Nizar G.& Hamad, Abd al W. R.. 2010. Relationship between interlukine-1 alpha and polyamines levels in serum and saliva as potential biomarkers in the diagnosis of oral squamous cell carcinoma. Journal of Baghdad College of Dentistry،Vol. 22, no. 1, pp.50-54.
https://search.emarefa.net/detail/BIM-288106
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gaphor, Shanaz M.…[et al.]. Relationship between interlukine-1 alpha and polyamines levels in serum and saliva as potential biomarkers in the diagnosis of oral squamous cell carcinoma. Journal of Baghdad College of Dentistry Vol. 22, no. 1 (2010), pp.50-54.
https://search.emarefa.net/detail/BIM-288106
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gaphor, Shanaz M.& al-Talabani, Nizar G.& Hamad, Abd al W. R.. Relationship between interlukine-1 alpha and polyamines levels in serum and saliva as potential biomarkers in the diagnosis of oral squamous cell carcinoma. Journal of Baghdad College of Dentistry. 2010. Vol. 22, no. 1, pp.50-54.
https://search.emarefa.net/detail/BIM-288106
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 53-54
رقم السجل
BIM-288106
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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