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Relationship between interlukine-1 alpha and polyamines levels in serum and saliva as potential biomarkers in the diagnosis of oral squamous cell carcinoma
Joint Authors
Gaphor, Shanaz M.
al-Talabani, Nizar G.
Hamad, Abd al W. R.
Source
Journal of Baghdad College of Dentistry
Issue
Vol. 22, Issue 1 (31 Mar. 2010), pp.50-54, 5 p.
Publisher
University of Baghdad College of Dentistry
Publication Date
2010-03-31
Country of Publication
Iraq
No. of Pages
5
Main Subjects
Topics
Abstract EN
Back ground: Oral cancer is one of the prevalent cancers of the body and is one of the 10 most common causes of death.
Oral squamous cell carcinoma (OSCC) accounts for over 90% of these tumors.
The aim of this study was designed to detect biochemical markers in serum and saliva of oral squamous cell carcinoma patients and to evaluate their validity in monitoring and diagnosis and to correlate relationship between IL-1 alpha and polyamines.
Patients and Methods : the level of polyamines in the serum and saliva of (30) patients with OSCC and (20) healthy individuals as control group was measured.
Level of proinflammatory cytokine Interleukin 1α (IL-1α) was detected by enzyme linked immunosorbent assay (ELISA).
Polyamines (spermidine and spermine) were determined by high performance liquid chromatography (HPLC) in both serum and saliva of patients with OSCC and control group.
Results and Discussion : salivary IL-1 alpha was useful in the diagnosis of OSCC patients.
The total serum and salivary polyamines level of OSCC were significantly higher than the control group (P < 0.001).
Both salivary and serum polyamines level were reliably accurate test in separating between OSCC patients and control group.
There was significant difference in salivary spermine level among OSCC patients in relation to lesion status.
Spermine levels were reduced in recurrent lesion especially with metastases.
There were significant differences in serum polyamines level among OSCC patients in relation to duration of the disease (P < 0.05).
Conclusion: There was a significant weak correlation between salivary IL-1α and salivary spermine (r = 0.377) (p < 0.05).
From the results of the presents study, it can be concluded that detection of polyamines in serum and saliva are useful and valuable diagnostic markers in diagnosis and early detection of OSCC.
American Psychological Association (APA)
Gaphor, Shanaz M.& al-Talabani, Nizar G.& Hamad, Abd al W. R.. 2010. Relationship between interlukine-1 alpha and polyamines levels in serum and saliva as potential biomarkers in the diagnosis of oral squamous cell carcinoma. Journal of Baghdad College of Dentistry،Vol. 22, no. 1, pp.50-54.
https://search.emarefa.net/detail/BIM-288106
Modern Language Association (MLA)
Gaphor, Shanaz M.…[et al.]. Relationship between interlukine-1 alpha and polyamines levels in serum and saliva as potential biomarkers in the diagnosis of oral squamous cell carcinoma. Journal of Baghdad College of Dentistry Vol. 22, no. 1 (2010), pp.50-54.
https://search.emarefa.net/detail/BIM-288106
American Medical Association (AMA)
Gaphor, Shanaz M.& al-Talabani, Nizar G.& Hamad, Abd al W. R.. Relationship between interlukine-1 alpha and polyamines levels in serum and saliva as potential biomarkers in the diagnosis of oral squamous cell carcinoma. Journal of Baghdad College of Dentistry. 2010. Vol. 22, no. 1, pp.50-54.
https://search.emarefa.net/detail/BIM-288106
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 53-54
Record ID
BIM-288106