Utility of free prostate specific antigen serum level and its related parameters in the diagnosis of prostate cancer
المؤلفون المشاركون
Harun, Azmi A.
al-Tarawinah, Imad S.
Awwad, Ziyad M.
Nimri, Caramella F.
Hadidi, Azmi S.
Muhafazah, Walid S.
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 22، العدد 2 (30 إبريل/نيسان 2011)، ص ص. 291-297، 7ص.
الناشر
تاريخ النشر
2011-04-30
دولة النشر
السعودية
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
الملخص EN
We evaluated the role of free prostate specific antigen (f-PSA) serum level and its related parameters in detecting prostate cancer.
This retrospective study was conducted between January 2006 and March 2008.
Trans-rectal ultrasound guided prostate biopsy was performed for 107 patients who had total PSA (t-PSA) level of either > 4 ng / mL with or without palpable nodule or ≤ 4 ng / mL with palpable nodule on digital rectal examination.
The performances measurements for f-PSA, percent free PSA (% f-PSA) and free PSA density (f-PSAD) were determined and compared with those for t-PSA and total PSA density (t-PSAD).
Descriptive statistics for all variables of interest were calculated, and receiver operating characteristic curves were generated.
Nine patients (8.4 %) had normal histology, 69 patients (64.4 %) had benign disease and 29 patients (27.1 %) had prostate cancer.
The performance of f-PSA in PCa detection was better than other evaluated parameters.
The largest area under the curve for patients in the gray area (t-PSA range 4.1–10 ng / mL) was for f-PSA, with a value of 0.64 and a sensitivity and specificity of 44 % and 87 %, respectively.
For % f-PSA, these values were 0.59, 63 % and 62 %, respectively.
For patients with a t-PSA level of 10.1–20 ng / mL, they were 0.68, 67 %, and 81 %, respectively, for f-PSA, and 0.64, 67 %, and 76 %, respectively, for %f-PSA.
In conclusion, f-PSA serum levels performed better than free to total PSA ratio and t-PSA for prostate cancer screening.
It is of clinical value which could affect the biopsy decision avoiding unnecessary interventions.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Harun, Azmi A.& Hadidi, Azmi S.& Awwad, Ziyad M.& Nimri, Caramella F.& Muhafazah, Walid S.& al-Tarawinah, Imad S.. 2011. Utility of free prostate specific antigen serum level and its related parameters in the diagnosis of prostate cancer. Saudi Journal of Kidney Diseases and Transplantation،Vol. 22, no. 2, pp.291-297.
https://search.emarefa.net/detail/BIM-291435
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Harun, Azmi A.…[et al.]. Utility of free prostate specific antigen serum level and its related parameters in the diagnosis of prostate cancer. Saudi Journal of Kidney Diseases and Transplantation Vol. 22, no. 2 (Apr. 2011), pp.291-297.
https://search.emarefa.net/detail/BIM-291435
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Harun, Azmi A.& Hadidi, Azmi S.& Awwad, Ziyad M.& Nimri, Caramella F.& Muhafazah, Walid S.& al-Tarawinah, Imad S.. Utility of free prostate specific antigen serum level and its related parameters in the diagnosis of prostate cancer. Saudi Journal of Kidney Diseases and Transplantation. 2011. Vol. 22, no. 2, pp.291-297.
https://search.emarefa.net/detail/BIM-291435
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 296-297
رقم السجل
BIM-291435
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر