Utility of free prostate specific antigen serum level and its related parameters in the diagnosis of prostate cancer
Joint Authors
Harun, Azmi A.
al-Tarawinah, Imad S.
Awwad, Ziyad M.
Nimri, Caramella F.
Hadidi, Azmi S.
Muhafazah, Walid S.
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 22, Issue 2 (30 Apr. 2011), pp.291-297, 7 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2011-04-30
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Topics
Abstract EN
We evaluated the role of free prostate specific antigen (f-PSA) serum level and its related parameters in detecting prostate cancer.
This retrospective study was conducted between January 2006 and March 2008.
Trans-rectal ultrasound guided prostate biopsy was performed for 107 patients who had total PSA (t-PSA) level of either > 4 ng / mL with or without palpable nodule or ≤ 4 ng / mL with palpable nodule on digital rectal examination.
The performances measurements for f-PSA, percent free PSA (% f-PSA) and free PSA density (f-PSAD) were determined and compared with those for t-PSA and total PSA density (t-PSAD).
Descriptive statistics for all variables of interest were calculated, and receiver operating characteristic curves were generated.
Nine patients (8.4 %) had normal histology, 69 patients (64.4 %) had benign disease and 29 patients (27.1 %) had prostate cancer.
The performance of f-PSA in PCa detection was better than other evaluated parameters.
The largest area under the curve for patients in the gray area (t-PSA range 4.1–10 ng / mL) was for f-PSA, with a value of 0.64 and a sensitivity and specificity of 44 % and 87 %, respectively.
For % f-PSA, these values were 0.59, 63 % and 62 %, respectively.
For patients with a t-PSA level of 10.1–20 ng / mL, they were 0.68, 67 %, and 81 %, respectively, for f-PSA, and 0.64, 67 %, and 76 %, respectively, for %f-PSA.
In conclusion, f-PSA serum levels performed better than free to total PSA ratio and t-PSA for prostate cancer screening.
It is of clinical value which could affect the biopsy decision avoiding unnecessary interventions.
American Psychological Association (APA)
Harun, Azmi A.& Hadidi, Azmi S.& Awwad, Ziyad M.& Nimri, Caramella F.& Muhafazah, Walid S.& al-Tarawinah, Imad S.. 2011. Utility of free prostate specific antigen serum level and its related parameters in the diagnosis of prostate cancer. Saudi Journal of Kidney Diseases and Transplantation،Vol. 22, no. 2, pp.291-297.
https://search.emarefa.net/detail/BIM-291435
Modern Language Association (MLA)
Harun, Azmi A.…[et al.]. Utility of free prostate specific antigen serum level and its related parameters in the diagnosis of prostate cancer. Saudi Journal of Kidney Diseases and Transplantation Vol. 22, no. 2 (Apr. 2011), pp.291-297.
https://search.emarefa.net/detail/BIM-291435
American Medical Association (AMA)
Harun, Azmi A.& Hadidi, Azmi S.& Awwad, Ziyad M.& Nimri, Caramella F.& Muhafazah, Walid S.& al-Tarawinah, Imad S.. Utility of free prostate specific antigen serum level and its related parameters in the diagnosis of prostate cancer. Saudi Journal of Kidney Diseases and Transplantation. 2011. Vol. 22, no. 2, pp.291-297.
https://search.emarefa.net/detail/BIM-291435
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 296-297
Record ID
BIM-291435