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Predictive value of immunohistochemical expression of claudin-1 in colonic carcinoma
المؤلفون المشاركون
Abd al-Zahir, Iman
Rizq, Azzah Muhammad
Bessa, Samer Sad
Umar, Khalaf Allah Mustafa
المصدر
Journal of the Egyptian National Cancer Institute
العدد
المجلد 23، العدد 4 (31 ديسمبر/كانون الأول 2011)، ص ص. 123-131، 9ص.
الناشر
جامعة القاهرة المعهد القومي للأورام
تاريخ النشر
2011-12-31
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الموضوعات
الملخص EN
Objective : colonic carcinoma is one of the most common cancers worldwide.
Recently, the possible involvement of claudin-1, one of the major tight junction proteins, in the process of tumorigenesis has been suggested.
Also, claudin-1 has emerged as a potential prognostic factor in different types of tumors.
The aim of this study was to detect caludin-1 expression in colonic carcinoma and to correlate its expression with clinicopathological variables in an attempt to delineate its role as a potential new prognostic marker.
Material and methods : Immunohistochemical expression of claudin-1 was assessed in 50 Egyptian patients with colonic adenocarcinoma.
The predictive performance of claudin-1 expression was statistically evaluated.
Results : decreased claudin-1 expression was found in 62 % of colonic adenocarcinoma cases while similar expression was found in 38 %.
Statistical analysis showed a statistically significant inverse correlation between claudin-1 expression and tumor grade, depth of invasion, lymph node involvement, and tumor stage.
Regression analysis showed that claudin-1 decreased expression significantly predicts that the tumor is of a high grade, high stage, and is associated with lymph node involvement.
ROC curve analysis showed that claudin-1 had a sensitivity of 88.24% and a specificity of 81.25 % for the prediction of tumor stage and a sensitivity of 73.33% and a specificity of 82.86 % for the prediction of lymph node involvement.
Conclusions : claudin-1 decreased expression in colonic carcinoma contributes to tumor dedifferentiation, invasion and metastasis.
Claudin-1 expression could be used as a predictor of colonic carcinoma stage and lymph node status with a high sensitivity and specificity.
ª 2011 National Cancer Institute, Cairo University.
Production and hosting by Elsevier B.V.
All rights reserved.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abd al-Zahir, Iman& Rizq, Azzah Muhammad& Bessa, Samer Sad& Umar, Khalaf Allah Mustafa. 2011. Predictive value of immunohistochemical expression of claudin-1 in colonic carcinoma. Journal of the Egyptian National Cancer Institute،Vol. 23, no. 4, pp.123-131.
https://search.emarefa.net/detail/BIM-292743
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rizq, Azzah Muhammad…[et al.]. Predictive value of immunohistochemical expression of claudin-1 in colonic carcinoma. Journal of the Egyptian National Cancer Institute Vol. 23, no. 4 (Dec. 2011), pp.123-131.
https://search.emarefa.net/detail/BIM-292743
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abd al-Zahir, Iman& Rizq, Azzah Muhammad& Bessa, Samer Sad& Umar, Khalaf Allah Mustafa. Predictive value of immunohistochemical expression of claudin-1 in colonic carcinoma. Journal of the Egyptian National Cancer Institute. 2011. Vol. 23, no. 4, pp.123-131.
https://search.emarefa.net/detail/BIM-292743
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 130-131
رقم السجل
BIM-292743
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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