Predictive value of immunohistochemical expression of claudin-1 in colonic carcinoma
Joint Authors
Abd al-Zahir, Iman
Rizq, Azzah Muhammad
Bessa, Samer Sad
Umar, Khalaf Allah Mustafa
Source
Journal of the Egyptian National Cancer Institute
Issue
Vol. 23, Issue 4 (31 Dec. 2011), pp.123-131, 9 p.
Publisher
Cairo University National Cancer Institute
Publication Date
2011-12-31
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Topics
Abstract EN
Objective : colonic carcinoma is one of the most common cancers worldwide.
Recently, the possible involvement of claudin-1, one of the major tight junction proteins, in the process of tumorigenesis has been suggested.
Also, claudin-1 has emerged as a potential prognostic factor in different types of tumors.
The aim of this study was to detect caludin-1 expression in colonic carcinoma and to correlate its expression with clinicopathological variables in an attempt to delineate its role as a potential new prognostic marker.
Material and methods : Immunohistochemical expression of claudin-1 was assessed in 50 Egyptian patients with colonic adenocarcinoma.
The predictive performance of claudin-1 expression was statistically evaluated.
Results : decreased claudin-1 expression was found in 62 % of colonic adenocarcinoma cases while similar expression was found in 38 %.
Statistical analysis showed a statistically significant inverse correlation between claudin-1 expression and tumor grade, depth of invasion, lymph node involvement, and tumor stage.
Regression analysis showed that claudin-1 decreased expression significantly predicts that the tumor is of a high grade, high stage, and is associated with lymph node involvement.
ROC curve analysis showed that claudin-1 had a sensitivity of 88.24% and a specificity of 81.25 % for the prediction of tumor stage and a sensitivity of 73.33% and a specificity of 82.86 % for the prediction of lymph node involvement.
Conclusions : claudin-1 decreased expression in colonic carcinoma contributes to tumor dedifferentiation, invasion and metastasis.
Claudin-1 expression could be used as a predictor of colonic carcinoma stage and lymph node status with a high sensitivity and specificity.
ª 2011 National Cancer Institute, Cairo University.
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American Psychological Association (APA)
Abd al-Zahir, Iman& Rizq, Azzah Muhammad& Bessa, Samer Sad& Umar, Khalaf Allah Mustafa. 2011. Predictive value of immunohistochemical expression of claudin-1 in colonic carcinoma. Journal of the Egyptian National Cancer Institute،Vol. 23, no. 4, pp.123-131.
https://search.emarefa.net/detail/BIM-292743
Modern Language Association (MLA)
Rizq, Azzah Muhammad…[et al.]. Predictive value of immunohistochemical expression of claudin-1 in colonic carcinoma. Journal of the Egyptian National Cancer Institute Vol. 23, no. 4 (Dec. 2011), pp.123-131.
https://search.emarefa.net/detail/BIM-292743
American Medical Association (AMA)
Abd al-Zahir, Iman& Rizq, Azzah Muhammad& Bessa, Samer Sad& Umar, Khalaf Allah Mustafa. Predictive value of immunohistochemical expression of claudin-1 in colonic carcinoma. Journal of the Egyptian National Cancer Institute. 2011. Vol. 23, no. 4, pp.123-131.
https://search.emarefa.net/detail/BIM-292743
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 130-131
Record ID
BIM-292743