Bleomycin induced pulmonary fibrosis

الملخص EN

Bleomycin is a widely used antineoplastic drug which produces dose and time-dependent interstitial pulmonary fibrosis in human and animals.

The mechanism of bleomycin-induced lung injury is not well understood.

However, current studies have shown that bleomycin can generate free oxygen radicals such as super -oxide and hydroxyl radical.

In this study the antioxidant effect of vitamin C in biological system and its effect on bleomycin-induced lung fibrosis in rat have been investigated.

In this study rats were divided into four groups : Control, bleomycin and Saline, bleomycin and vitamin C and saline and vitamin C.

The degree of tissue injury in the bleomycin and vitamin C group was significantly lower than bleomycin and saline group.

Results of this study suggest that vitamin C may reduce the fibrosis formation effect of neomycin in lung tissue.