Bleomycin induced pulmonary fibrosis
Joint Authors
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 7, Issue 3 (31 Jan. 2005), pp.18-20, 3 p.
Publisher
Publication Date
2005-01-31
Country of Publication
United Arab Emirates
No. of Pages
3
Main Subjects
Topics
Abstract EN
Bleomycin is a widely used antineoplastic drug which produces dose and time-dependent interstitial pulmonary fibrosis in human and animals.
The mechanism of bleomycin-induced lung injury is not well understood.
However, current studies have shown that bleomycin can generate free oxygen radicals such as super -oxide and hydroxyl radical.
In this study the antioxidant effect of vitamin C in biological system and its effect on bleomycin-induced lung fibrosis in rat have been investigated.
In this study rats were divided into four groups : Control, bleomycin and Saline, bleomycin and vitamin C and saline and vitamin C.
The degree of tissue injury in the bleomycin and vitamin C group was significantly lower than bleomycin and saline group.
Results of this study suggest that vitamin C may reduce the fibrosis formation effect of neomycin in lung tissue.
American Psychological Association (APA)
Rashidi, I.& Mozaffari, A. R.. 2005. Bleomycin induced pulmonary fibrosis. Iranian Red Crescent Medical Journal،Vol. 7, no. 3, pp.18-20.
https://search.emarefa.net/detail/BIM-29984
Modern Language Association (MLA)
Rashidi, I.& Mozaffari, A. R.. Bleomycin induced pulmonary fibrosis. Iranian Red Crescent Medical Journal Vol. 7, no. 3 (Jan. 2005), pp.18-20.
https://search.emarefa.net/detail/BIM-29984
American Medical Association (AMA)
Rashidi, I.& Mozaffari, A. R.. Bleomycin induced pulmonary fibrosis. Iranian Red Crescent Medical Journal. 2005. Vol. 7, no. 3, pp.18-20.
https://search.emarefa.net/detail/BIM-29984
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 20
Record ID
BIM-29984
