High sensitive CRP (hs-CRP)‎ as a marker for coronary heart disease (CHD)‎ in Ramallah area- Palestine

العناوين الأخرى

س.ر.بي الحساس كعامل لأمراض القلب في منطقة رام الله-فلسطين

مقدم أطروحة جامعية

Dahir, Husam Arif

مشرف أطروحة جامعية

al-Khayri, Lina
Khuri, Juni

أعضاء اللجنة

Hammudah, Wail
Farraj, Muhammad A.

الجامعة

جامعة بيرزيت

الكلية

كلية العلوم

القسم الأكاديمي

دائرة الأحياء و الكيمياء الحيوية

دولة الجامعة

فلسطين (الضفة الغربية)

الدرجة العلمية

ماجستير

تاريخ الدرجة العلمية

2008

الملخص الإنجليزي

Mortality from (CHD) is the highest worldwide.

For long time it has been associated with high lipids concentration, mainly LDL-C.

About 50-60 % of cases associated with CHD were diagnosed by lipid screening profile.

This profile failed to diagnose people who had a high risk for CHD in certain cases, and in some cases associated with normal LDL-C.

Because of this, scientists are trying to identify other risk factors that may help in diagnosing people with high risk for developing future CHD.

Atherosclerosis is considered an inflammatory and atherogenic disease.

As a result, inflammatory factors are considered as the most important factors in this aspect.

C - reactive protein (CRP) measured by high sensitive methods is considered the most predictive factor associated with future coronary heart disease.

In this case–control study, we have selected 160 subjects (80 cases and 80 controls) from the West Bank.

Controls were free of CHD, while cases were diagnosed to have CHD.

Both groups had the same conditional risk factors, such as smoking, hypertension, diabetes, and dyslipidemia.

Hs-CRP measured by ELISA methods for both groups to find out the association between levels of hs- CRP and CHD.

In addition a comparison between hs-CRP and LDL-C in predicting future detection rate of CHD were studied.

It was found that there was a statistically significant relationship between hs-CRP and CHD, P < 0.005 using independent t-test.

The odds ratio for equal quartiles of hs-CRP between control and cases were found to be 4.25 95 % CI (2.34-7.22).

hs-CRP greater than 3.0 mg / L and LDL-C less than 130 mg/dl odds ratio was 7.66 with 95 % CI (2.5-23.4) compared to the reference group( Low CRP / Low LDL-C).

These finding indicated the importance of adding hs-CRP to lipid screening profile.

In this study it was found that hs-CRP can be considered a good predictor for events associated with CHD more than LDL-C, and clinically can be added with T-cholesterol / HDL-C ratio to predict the risk for CHD.

التخصصات الرئيسية

الطب البشري

الموضوعات

• القلب
• الأمراض
• أمراض القلب التاجية
• فلسطين
• رام الله
• بروتينات الطور الحاد
• التشخيص

عدد الصفحات

31

قائمة المحتويات

• APA
• MLA
• AMA

لغة النص

الإنجليزية

نوع البيانات

رسائل جامعية

رقم السجل

BIM-303596