High sensitive CRP (hs-CRP) as a marker for coronary heart disease (CHD) in Ramallah area- Palestine
Other Title(s)
س.ر.بي الحساس كعامل لأمراض القلب في منطقة رام الله-فلسطين
Dissertant
Thesis advisor
Comitee Members
Hammudah, Wail
Farraj, Muhammad A.
University
Birzeit University
Faculty
Faculty of Science
Department
Department Nutrition and Dietetics
University Country
Palestine (West Bank)
Degree
Master
Degree Date
2008
English Abstract
Mortality from (CHD) is the highest worldwide.
For long time it has been associated with high lipids concentration, mainly LDL-C.
About 50-60 % of cases associated with CHD were diagnosed by lipid screening profile.
This profile failed to diagnose people who had a high risk for CHD in certain cases, and in some cases associated with normal LDL-C.
Because of this, scientists are trying to identify other risk factors that may help in diagnosing people with high risk for developing future CHD.
Atherosclerosis is considered an inflammatory and atherogenic disease.
As a result, inflammatory factors are considered as the most important factors in this aspect.
C - reactive protein (CRP) measured by high sensitive methods is considered the most predictive factor associated with future coronary heart disease.
In this case–control study, we have selected 160 subjects (80 cases and 80 controls) from the West Bank.
Controls were free of CHD, while cases were diagnosed to have CHD.
Both groups had the same conditional risk factors, such as smoking, hypertension, diabetes, and dyslipidemia.
Hs-CRP measured by ELISA methods for both groups to find out the association between levels of hs- CRP and CHD.
In addition a comparison between hs-CRP and LDL-C in predicting future detection rate of CHD were studied.
It was found that there was a statistically significant relationship between hs-CRP and CHD, P < 0.005 using independent t-test.
The odds ratio for equal quartiles of hs-CRP between control and cases were found to be 4.25 95 % CI (2.34-7.22).
hs-CRP greater than 3.0 mg / L and LDL-C less than 130 mg/dl odds ratio was 7.66 with 95 % CI (2.5-23.4) compared to the reference group( Low CRP / Low LDL-C).
These finding indicated the importance of adding hs-CRP to lipid screening profile.
In this study it was found that hs-CRP can be considered a good predictor for events associated with CHD more than LDL-C, and clinically can be added with T-cholesterol / HDL-C ratio to predict the risk for CHD.
Main Subjects
Topics
No. of Pages
31
Table of Contents
Table of contents.
Abstract.
Chapter One : introduction.
Chapter Two : materials and methods.
Chapter Three : results and discussion.
Chapter Four : conclusion.
Deferences.
American Psychological Association (APA)
Dahir, Husam Arif. (2008). High sensitive CRP (hs-CRP) as a marker for coronary heart disease (CHD) in Ramallah area- Palestine. (Master's theses Theses and Dissertations Master). Birzeit University, Palestine (West Bank)
https://search.emarefa.net/detail/BIM-303596
Modern Language Association (MLA)
Dahir, Husam Arif. High sensitive CRP (hs-CRP) as a marker for coronary heart disease (CHD) in Ramallah area- Palestine. (Master's theses Theses and Dissertations Master). Birzeit University. (2008).
https://search.emarefa.net/detail/BIM-303596
American Medical Association (AMA)
Dahir, Husam Arif. (2008). High sensitive CRP (hs-CRP) as a marker for coronary heart disease (CHD) in Ramallah area- Palestine. (Master's theses Theses and Dissertations Master). Birzeit University, Palestine (West Bank)
https://search.emarefa.net/detail/BIM-303596
Language
English
Data Type
Arab Theses
Record ID
BIM-303596
