Oxidative stress in uremia

العناوين الأخرى

تأثير المؤكسدات على مرضى الفشل الكلوي

مقدم أطروحة جامعية

al-Saub, Razan A. W.

مشرف أطروحة جامعية

Abbud, Muayyad Mahdi

أعضاء اللجنة

al-Tarawinah, Khalid Ahmad Jafar
Ababinah, Ahmad Husayn
Farjw, Imad al-Din Bashir

الجامعة

جامعة مؤتة

الكلية

كلية العلوم

القسم الأكاديمي

قسم الأحياء

دولة الجامعة

الأردن

الدرجة العلمية

ماجستير

تاريخ الدرجة العلمية

2007

الملخص الإنجليزي

Oxidative stress in renal patients was investigated by determining the degree of in vitro hemolysis in two groups of uremic patients, newly diagnosed and patients under dialysis.

This oxidative stress was compared with normal subjects.

The most effective hemolytic agents were found to be nitrosocysteine, nitrosoarginine, sodium dodecyl sulfate (SDS), cysteine, and salicylic acid.

These compounds produced a maximum hemolysis of more than 50 % in uremic patients.

Other compounds like spermidine, methionine, urea, alanine, and arginine had maximum hemolysis of less than 10% in uremic patients and therefore considered weak hemolytic agents.

Regardless of the hemolytic agent being used, the hemolytic effect was concentration dependent and more pronounced in newly diagnosed than in renal patients under dialysis. Aqueous extracts of some antioxidant herbal plants were able to protect against in vitro hemolysis of uremic RBC by cysteine in pattern analogous to the action of known antioxidants like uric acid, ascorbic acid and trolox.

The order of hemolytic protection by these herbal plants was Rhus coriaria, Brassica nigra, Trigonella foenum, Dianthus caryophyllus, Nigella sativa and Boswellia carterii.

A similar herbal protection was produced against nitrosocysteine and SDS hemolytic agents. When the same herbal plants were used against experimental uremia induced in rats by 50% glycerol, all plants were able to reduce the level of plasma urea significantly from the abnormal level of untreated rats.

However, the order of uremic treatment efficiency was not completely matching the herbal order of in vitro hemolytic protection.

It seems therefore that the in vitro hemolytic protection of these antioxidants plants is aligned with their in vivo antiuremic action.

التخصصات الرئيسية

الطب البشري

الموضوعات

• الإجهاد التأكسدي
• الكلى
• الأمراض

عدد الصفحات

70

قائمة المحتويات

• APA
• MLA
• AMA

لغة النص

الإنجليزية

نوع البيانات

رسائل جامعية

رقم السجل

BIM-304493