Oxidative stress in uremia
Other Title(s)
تأثير المؤكسدات على مرضى الفشل الكلوي
Dissertant
Thesis advisor
Comitee Members
al-Tarawinah, Khalid Ahmad Jafar
Ababinah, Ahmad Husayn
Farjw, Imad al-Din Bashir
University
Mutah University
Faculty
Faculty of Science
Department
Department of Biological Sciences
University Country
Jordan
Degree
Master
Degree Date
2007
English Abstract
Oxidative stress in renal patients was investigated by determining the degree of in vitro hemolysis in two groups of uremic patients, newly diagnosed and patients under dialysis.
This oxidative stress was compared with normal subjects.
The most effective hemolytic agents were found to be nitrosocysteine, nitrosoarginine, sodium dodecyl sulfate (SDS), cysteine, and salicylic acid.
These compounds produced a maximum hemolysis of more than 50 % in uremic patients.
Other compounds like spermidine, methionine, urea, alanine, and arginine had maximum hemolysis of less than 10% in uremic patients and therefore considered weak hemolytic agents.
Regardless of the hemolytic agent being used, the hemolytic effect was concentration dependent and more pronounced in newly diagnosed than in renal patients under dialysis. Aqueous extracts of some antioxidant herbal plants were able to protect against in vitro hemolysis of uremic RBC by cysteine in pattern analogous to the action of known antioxidants like uric acid, ascorbic acid and trolox.
The order of hemolytic protection by these herbal plants was Rhus coriaria, Brassica nigra, Trigonella foenum, Dianthus caryophyllus, Nigella sativa and Boswellia carterii.
A similar herbal protection was produced against nitrosocysteine and SDS hemolytic agents. When the same herbal plants were used against experimental uremia induced in rats by 50% glycerol, all plants were able to reduce the level of plasma urea significantly from the abnormal level of untreated rats.
However, the order of uremic treatment efficiency was not completely matching the herbal order of in vitro hemolytic protection.
It seems therefore that the in vitro hemolytic protection of these antioxidants plants is aligned with their in vivo antiuremic action.
Main Subjects
Topics
No. of Pages
70
Table of Contents
Table of contents.
Abstract.
Chapter one : Theoretical background.
Chapter two : Literature review.
Chapter three : Design and methodology.
Chapter four : Results.
Chapter five : Discussion, conclusion, and recommendations.
References.
American Psychological Association (APA)
al-Saub, Razan A. W.. (2007). Oxidative stress in uremia. (Master's theses Theses and Dissertations Master). Mutah University, Jordan
https://search.emarefa.net/detail/BIM-304493
Modern Language Association (MLA)
al-Saub, Razan A. W.. Oxidative stress in uremia. (Master's theses Theses and Dissertations Master). Mutah University. (2007).
https://search.emarefa.net/detail/BIM-304493
American Medical Association (AMA)
al-Saub, Razan A. W.. (2007). Oxidative stress in uremia. (Master's theses Theses and Dissertations Master). Mutah University, Jordan
https://search.emarefa.net/detail/BIM-304493
Language
English
Data Type
Arab Theses
Record ID
BIM-304493
