Studying the effect of a maltitol solution on the stability of water soluble vitamins

الملخص EN

The stability of vitamins in a liquid dosage form is still considered a challenge to pharmacists to obtain a stable formula.

The objective of this study was to formulate multi-water soluble vitamin oral solutions, study the stability of this formulation at accelerated conditions 40 ± 2 o C / 75 % ± 5 % RH for two months and investigate the effect of the pH and the percent of a maltitol solution on the stability of the vitamins.

Results showed that using a 30 % maltitol solution gave a pronounced improvement in the stability of vitamins compared with a sorbitol solution, and the pH had a critical role on the stability of vitamins so the vitamins had an optimum stability at pH between3.5–4.