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Long-term outcome of the difficult nephrotic syndrome in children
المؤلفون المشاركون
al-Hasan, Khalid
al-Ibrahim, Alia Abd al-Rahim
al-Sallum, Abd Allah A.
Muthanna, Ahmad
Bassrawi, Rulan
al-Shihab, Azizah A.
Zahid al-Islam, Muhammad
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 23، العدد 5 (31 أكتوبر/تشرين الأول 2012)، ص ص. 965-972، 8ص.
الناشر
تاريخ النشر
2012-10-31
دولة النشر
السعودية
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
To determine the long-term outcome of nephrotic syndrome (NS) in children, we studied 48 patients with the NS aged seven months to 12 years at onset and followed for a long period (3–9 years).
Consanguinity was positive in 31.2 %.
Patients’ history of atopy was present in while family history of allergy was present in 18 (37.5 %) patients.
Renal impairment at initial presentation was observed in 12.5 % of the patients.
Among 32 biopsied patients, 11 (34.3 %) had focal segmental glomerulosclerosis and eight (25 %) revealed mesangial IgM nephropathy.
Outcome at two years of presentation showed 41.6 % patients as frequent relapsers, 39.5 % as steroid dependent and18.7 % as steroid resistant.
Forty-three patients were available for follow-up after ten years of presentation, 22 (51 %) patients had complete remission, 15 (34.8 %) were steroid dependent, two (4.6 %) developed chronic renal failure and two (4.6 %) died.
Two patients (4.6 %) developed insulin-dependent diabetes mellitus, two (4.6 %) had cataract and one (2.3 %) had documented peritonitis.
In conclusion, the high incidence of steroid-dependent frequent relapses and steroid resistance in children can be explained by different factors, including consanguinity, atopy and severe presentation at onset of disease.
We suggest longer initial treatment at onset for this group of patients.
The low incidence of infection in this group needs to be addressed in future studies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Sallum, Abd Allah A.& Muthanna, Ahmad& Bassrawi, Rulan& al-Shihab, Azizah A.& al-Ibrahim, Alia Abd al-Rahim& Zahid al-Islam, Muhammad…[et al.]. 2012. Long-term outcome of the difficult nephrotic syndrome in children. Saudi Journal of Kidney Diseases and Transplantation،Vol. 23, no. 5, pp.965-972.
https://search.emarefa.net/detail/BIM-311759
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Sallum, Abd Allah A.…[et al.]. Long-term outcome of the difficult nephrotic syndrome in children. Saudi Journal of Kidney Diseases and Transplantation Vol. 23, no. 5 (Oct. 2012), pp.965-972.
https://search.emarefa.net/detail/BIM-311759
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Sallum, Abd Allah A.& Muthanna, Ahmad& Bassrawi, Rulan& al-Shihab, Azizah A.& al-Ibrahim, Alia Abd al-Rahim& Zahid al-Islam, Muhammad…[et al.]. Long-term outcome of the difficult nephrotic syndrome in children. Saudi Journal of Kidney Diseases and Transplantation. 2012. Vol. 23, no. 5, pp.965-972.
https://search.emarefa.net/detail/BIM-311759
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 971-972
رقم السجل
BIM-311759
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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