Long-term outcome of the difficult nephrotic syndrome in children
Joint Authors
al-Hasan, Khalid
al-Ibrahim, Alia Abd al-Rahim
al-Sallum, Abd Allah A.
Muthanna, Ahmad
Bassrawi, Rulan
al-Shihab, Azizah A.
Zahid al-Islam, Muhammad
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 23, Issue 5 (31 Oct. 2012), pp.965-972, 8 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2012-10-31
Country of Publication
Saudi Arabia
No. of Pages
8
Main Subjects
Abstract EN
To determine the long-term outcome of nephrotic syndrome (NS) in children, we studied 48 patients with the NS aged seven months to 12 years at onset and followed for a long period (3–9 years).
Consanguinity was positive in 31.2 %.
Patients’ history of atopy was present in while family history of allergy was present in 18 (37.5 %) patients.
Renal impairment at initial presentation was observed in 12.5 % of the patients.
Among 32 biopsied patients, 11 (34.3 %) had focal segmental glomerulosclerosis and eight (25 %) revealed mesangial IgM nephropathy.
Outcome at two years of presentation showed 41.6 % patients as frequent relapsers, 39.5 % as steroid dependent and18.7 % as steroid resistant.
Forty-three patients were available for follow-up after ten years of presentation, 22 (51 %) patients had complete remission, 15 (34.8 %) were steroid dependent, two (4.6 %) developed chronic renal failure and two (4.6 %) died.
Two patients (4.6 %) developed insulin-dependent diabetes mellitus, two (4.6 %) had cataract and one (2.3 %) had documented peritonitis.
In conclusion, the high incidence of steroid-dependent frequent relapses and steroid resistance in children can be explained by different factors, including consanguinity, atopy and severe presentation at onset of disease.
We suggest longer initial treatment at onset for this group of patients.
The low incidence of infection in this group needs to be addressed in future studies.
American Psychological Association (APA)
al-Sallum, Abd Allah A.& Muthanna, Ahmad& Bassrawi, Rulan& al-Shihab, Azizah A.& al-Ibrahim, Alia Abd al-Rahim& Zahid al-Islam, Muhammad…[et al.]. 2012. Long-term outcome of the difficult nephrotic syndrome in children. Saudi Journal of Kidney Diseases and Transplantation،Vol. 23, no. 5, pp.965-972.
https://search.emarefa.net/detail/BIM-311759
Modern Language Association (MLA)
al-Sallum, Abd Allah A.…[et al.]. Long-term outcome of the difficult nephrotic syndrome in children. Saudi Journal of Kidney Diseases and Transplantation Vol. 23, no. 5 (Oct. 2012), pp.965-972.
https://search.emarefa.net/detail/BIM-311759
American Medical Association (AMA)
al-Sallum, Abd Allah A.& Muthanna, Ahmad& Bassrawi, Rulan& al-Shihab, Azizah A.& al-Ibrahim, Alia Abd al-Rahim& Zahid al-Islam, Muhammad…[et al.]. Long-term outcome of the difficult nephrotic syndrome in children. Saudi Journal of Kidney Diseases and Transplantation. 2012. Vol. 23, no. 5, pp.965-972.
https://search.emarefa.net/detail/BIM-311759
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 971-972
Record ID
BIM-311759