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Expression of angiotensin-converting enzyme mRNA gene in the kidneys of patients with glomerulonephrites
المؤلفون المشاركون
al-Nahal, al-Sayyid Ahmad
Dhiyab, Magada al-Sayyid
Zanaty, Ali Fahmi
Khalil, Usamah Ahmad
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 23، العدد 5 (31 أكتوبر/تشرين الأول 2012)، ص ص. 993-999، 7ص.
الناشر
تاريخ النشر
2012-10-31
دولة النشر
السعودية
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
الملخص EN
A little is known about the behavior of the renin–angiotensin system (RAS) in glomerulo-nephritis (GN), although it is activated in other models of injury.
To study renal angiotensin- converting enzyme (ACE) messenger ribonucleic acid (mRNA) gene expression in patients with GN to determine its role in the disease process and other factors that may influence the course of the disease and the prognosis, e.
g.
treatment with ACE inhibitor (ACEI) drugs, we studied 20 patients with GN allocated to two groups : ten patients received an ACEI drug and ten patients did not receive ACEI in addition to a control group of ten healthy subjects.
Routine and special laboratory investigation, histopathological studies and quantitative polymerase chain reaction analysis for renal ACE mRNA were done for both the study and the control groups.
There was a statistically significant increase in ACE mRNA gene expression in the GN groups than in control group, but no statistically significant difference in ACE mRNA gene expression between the patients group that received and the group that did not receive ACEI.
A significant correlation was found between the ACE mRNA gene expression and the mean blood pressure, serum creatinine, blood urea nitrogen and 24-h urinary protein.
In conclusion, a higher level of ACE mRNA gene expression in patients suffering from GN may suggest a role of the RAS in the process of GN, perhaps contributing to glomerular hypertrophy and matrix overproduction.
The use of ACEI drugs possibly slows the rate of progression of renal failure and plays a role in controlling the pathophysiology.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Nahal, al-Sayyid Ahmad& Khalil, Usamah Ahmad& Dhiyab, Magada al-Sayyid& Zanaty, Ali Fahmi. 2012. Expression of angiotensin-converting enzyme mRNA gene in the kidneys of patients with glomerulonephrites. Saudi Journal of Kidney Diseases and Transplantation،Vol. 23, no. 5, pp.993-999.
https://search.emarefa.net/detail/BIM-311771
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Nahal, al-Sayyid Ahmad…[et al.]. Expression of angiotensin-converting enzyme mRNA gene in the kidneys of patients with glomerulonephrites. Saudi Journal of Kidney Diseases and Transplantation Vol. 23, no. 5 (Oct. 2012), pp.993-999.
https://search.emarefa.net/detail/BIM-311771
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Nahal, al-Sayyid Ahmad& Khalil, Usamah Ahmad& Dhiyab, Magada al-Sayyid& Zanaty, Ali Fahmi. Expression of angiotensin-converting enzyme mRNA gene in the kidneys of patients with glomerulonephrites. Saudi Journal of Kidney Diseases and Transplantation. 2012. Vol. 23, no. 5, pp.993-999.
https://search.emarefa.net/detail/BIM-311771
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 998-999
رقم السجل
BIM-311771
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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