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Expression of angiotensin-converting enzyme mRNA gene in the kidneys of patients with glomerulonephrites
Joint Authors
al-Nahal, al-Sayyid Ahmad
Dhiyab, Magada al-Sayyid
Zanaty, Ali Fahmi
Khalil, Usamah Ahmad
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 23, Issue 5 (31 Oct. 2012), pp.993-999, 7 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2012-10-31
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Topics
Abstract EN
A little is known about the behavior of the renin–angiotensin system (RAS) in glomerulo-nephritis (GN), although it is activated in other models of injury.
To study renal angiotensin- converting enzyme (ACE) messenger ribonucleic acid (mRNA) gene expression in patients with GN to determine its role in the disease process and other factors that may influence the course of the disease and the prognosis, e.
g.
treatment with ACE inhibitor (ACEI) drugs, we studied 20 patients with GN allocated to two groups : ten patients received an ACEI drug and ten patients did not receive ACEI in addition to a control group of ten healthy subjects.
Routine and special laboratory investigation, histopathological studies and quantitative polymerase chain reaction analysis for renal ACE mRNA were done for both the study and the control groups.
There was a statistically significant increase in ACE mRNA gene expression in the GN groups than in control group, but no statistically significant difference in ACE mRNA gene expression between the patients group that received and the group that did not receive ACEI.
A significant correlation was found between the ACE mRNA gene expression and the mean blood pressure, serum creatinine, blood urea nitrogen and 24-h urinary protein.
In conclusion, a higher level of ACE mRNA gene expression in patients suffering from GN may suggest a role of the RAS in the process of GN, perhaps contributing to glomerular hypertrophy and matrix overproduction.
The use of ACEI drugs possibly slows the rate of progression of renal failure and plays a role in controlling the pathophysiology.
American Psychological Association (APA)
al-Nahal, al-Sayyid Ahmad& Khalil, Usamah Ahmad& Dhiyab, Magada al-Sayyid& Zanaty, Ali Fahmi. 2012. Expression of angiotensin-converting enzyme mRNA gene in the kidneys of patients with glomerulonephrites. Saudi Journal of Kidney Diseases and Transplantation،Vol. 23, no. 5, pp.993-999.
https://search.emarefa.net/detail/BIM-311771
Modern Language Association (MLA)
al-Nahal, al-Sayyid Ahmad…[et al.]. Expression of angiotensin-converting enzyme mRNA gene in the kidneys of patients with glomerulonephrites. Saudi Journal of Kidney Diseases and Transplantation Vol. 23, no. 5 (Oct. 2012), pp.993-999.
https://search.emarefa.net/detail/BIM-311771
American Medical Association (AMA)
al-Nahal, al-Sayyid Ahmad& Khalil, Usamah Ahmad& Dhiyab, Magada al-Sayyid& Zanaty, Ali Fahmi. Expression of angiotensin-converting enzyme mRNA gene in the kidneys of patients with glomerulonephrites. Saudi Journal of Kidney Diseases and Transplantation. 2012. Vol. 23, no. 5, pp.993-999.
https://search.emarefa.net/detail/BIM-311771
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 998-999
Record ID
BIM-311771