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Adiponectin to leptin ratio as a potential antiatherogenic index in egyptian patients with type 2 diabetes mellitus
المؤلفون المشاركون
Sheriba, Nirmin Ahmad
Najati, Majidah Muhammad
Ahmad, Manal Basyuni
Abd al-Wahhab, Dalia
المصدر
The Egyptian Journal of Biochemistry and Molecular Biology
العدد
المجلد 29، العدد 1 (30 يونيو/حزيران 2011)، ص ص. 65-78، 14ص.
الناشر
الجمعية المصرية للكيمياء الحيوية و البيولوجيا الجزيئية
تاريخ النشر
2011-06-30
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الموضوعات
الملخص EN
It has been demonstrated in recent studies that abnormal levels of adipocytokines may contribute to insulin resistance and type 2 diabetes.
We aimed to assess the potential role of the adiponectin to leptin ratio (A / L ratio) as a biomarker for atherosclerosis and glycemic control in type 2 diabetic patients.
The serum levels of adiponectin, leptin were measured simultaneously by enzyme-linked immunosorbent assay.
Their levels and ratio were correlated to CRP, glycemic status and lipid profile in 60 type 2 diabetic patients compared to 30 healthy subjects.
We found a significant higher leptin and C-reactive protein (CRP) with lower adiponectin and A / L ratio in non-controlled type 2 diabetes comparing to health and controlled diabetic patients.
Moreover, obese subjects had higher Leptin with lower adiponectin and A / L ratio than non-obese subjects.
Persons with complicated diabetes mellitus were higher among uncontrolled DM ; they had higher leptin with lower A / L ratio compared to non-complicated diabetic patients.
Leptin was negatively correlated to adiponectin (r = -0.63).
Atherogenic index was positively correlated to leptin (r = 0.778) and negatively correlated to adiponectin (r = -0.756) and A / L ratio (r= -0.713).
Moreover, A / L ratio correlated negatively to CRP, HbA1c, FBG and BMI.
This study confirms the role of adiponectin and leptin levels in DM control and severity of dyslipidemia.
We found A / L ratio is better than each marker alone to evaluate atherogenicity in DM and may serve as an anti-atherogenic index and may be act as a new marker of metabolic control for individuals with high risk of cardiovascular complications of atherosclerosis in type II diabetes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Najati, Majidah Muhammad& Ahmad, Manal Basyuni& Abd al-Wahhab, Dalia& Sheriba, Nirmin Ahmad. 2011. Adiponectin to leptin ratio as a potential antiatherogenic index in egyptian patients with type 2 diabetes mellitus. The Egyptian Journal of Biochemistry and Molecular Biology،Vol. 29, no. 1, pp.65-78.
https://search.emarefa.net/detail/BIM-312381
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Najati, Majidah Muhammad…[et al.]. Adiponectin to leptin ratio as a potential antiatherogenic index in egyptian patients with type 2 diabetes mellitus. The Egyptian Journal of Biochemistry and Molecular Biology Vol. 29, no. 1 (Jun. 2011), pp.65-78.
https://search.emarefa.net/detail/BIM-312381
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Najati, Majidah Muhammad& Ahmad, Manal Basyuni& Abd al-Wahhab, Dalia& Sheriba, Nirmin Ahmad. Adiponectin to leptin ratio as a potential antiatherogenic index in egyptian patients with type 2 diabetes mellitus. The Egyptian Journal of Biochemistry and Molecular Biology. 2011. Vol. 29, no. 1, pp.65-78.
https://search.emarefa.net/detail/BIM-312381
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 76-78
رقم السجل
BIM-312381
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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