Adiponectin to leptin ratio as a potential antiatherogenic index in egyptian patients with type 2 diabetes mellitus

Abstract EN

It has been demonstrated in recent studies that abnormal levels of adipocytokines may contribute to insulin resistance and type 2 diabetes.

We aimed to assess the potential role of the adiponectin to leptin ratio (A / L ratio) as a biomarker for atherosclerosis and glycemic control in type 2 diabetic patients.

The serum levels of adiponectin, leptin were measured simultaneously by enzyme-linked immunosorbent assay.

Their levels and ratio were correlated to CRP, glycemic status and lipid profile in 60 type 2 diabetic patients compared to 30 healthy subjects.

We found a significant higher leptin and C-reactive protein (CRP) with lower adiponectin and A / L ratio in non-controlled type 2 diabetes comparing to health and controlled diabetic patients.

Moreover, obese subjects had higher Leptin with lower adiponectin and A / L ratio than non-obese subjects.

Persons with complicated diabetes mellitus were higher among uncontrolled DM ; they had higher leptin with lower A / L ratio compared to non-complicated diabetic patients.

Leptin was negatively correlated to adiponectin (r = -0.63).

Atherogenic index was positively correlated to leptin (r = 0.778) and negatively correlated to adiponectin (r = -0.756) and A / L ratio (r= -0.713).

Moreover, A / L ratio correlated negatively to CRP, HbA1c, FBG and BMI.

This study confirms the role of adiponectin and leptin levels in DM control and severity of dyslipidemia.

We found A / L ratio is better than each marker alone to evaluate atherogenicity in DM and may serve as an anti-atherogenic index and may be act as a new marker of metabolic control for individuals with high risk of cardiovascular complications of atherosclerosis in type II diabetes.