Homocysteine, folic acid and vitamin B12 levels in serum of epileptic children
المؤلفون المشاركون
Nur al-Din, Usamah
Abd al-Dayim, Suha M.
Shatla, Raniayh Hamid
Imarah, Nahed A.
al-Jammal, Sarah S.
المصدر
The Egyptian Journal of Medical Human Genetics
العدد
المجلد 13، العدد 3 (31 ديسمبر/كانون الأول 2012)، ص ص. 275-280، 6ص.
الناشر
الجمعية المصرية للأمراض الوراثية
تاريخ النشر
2012-12-31
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الموضوعات
الملخص EN
The relationship between increased homocysteine (Hcy) level and epileptic seizure remains controversial in human, despite a growing evidence of the pro-convulsive effect of the hyperhomocysteinemia (HHcy) observed in the animal studies.
The mechanism of this association with epileptogenesis has not been clearly understood, although there is emerging evidence to support the unfavorable effects of some anti-epileptic drugs (AEDs) on the plasma homocysteine (Hcy) concentrations.
The aim of this study was to uncover the relationship between the levels of homocysteine (Hcy), the cofactors involved in its metabolism as folic acid and vitamin B12 and anti-epileptic drugs (AEDs) in epileptic patients.
Serum level of homocysteine (Hcy), folic acid and vitamin B12 was measured in 60 patients with idiopathic epilepsy; and its level was compared to 30 healthy children serving as control group.
No significant difference was found regarding the plasma homocysteine (Hcy) levels between patients (both receiving anti-epileptics and non-anti-epileptic drug users) and controls.
Epileptic patients on polytherapy showed higher mean serum levels of homocysteine (Hcy) and lower mean serum levels of folic acid compared to those on immunotherapy.
However, the mean serum levels of homocysteine (Hcy), vitamin B12 and folic acid showed non-significant differences between patients using valproic acid (VPA) or carbamazepine (CBZ).
Duration of AED therapy showed a significant positive correlation with mean serum levels of homocysteine (Hcy) and a significant negative correlation with mean serum levels of folic acid.
To conclude ; AEDs upset the homeostatic balance of homocysteine (Hcy) and its cofactors and cause abnormalities in their serum levels.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nur al-Din, Usamah& Abd al-Dayim, Suha M.& Shatla, Raniayh Hamid& Imarah, Nahed A.& al-Jammal, Sarah S.. 2012. Homocysteine, folic acid and vitamin B12 levels in serum of epileptic children. The Egyptian Journal of Medical Human Genetics،Vol. 13, no. 3, pp.275-280.
https://search.emarefa.net/detail/BIM-313013
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nur al-Din, Usamah…[et al.]. Homocysteine, folic acid and vitamin B12 levels in serum of epileptic children. The Egyptian Journal of Medical Human Genetics Vol. 13, no. 3 (2012), pp.275-280.
https://search.emarefa.net/detail/BIM-313013
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nur al-Din, Usamah& Abd al-Dayim, Suha M.& Shatla, Raniayh Hamid& Imarah, Nahed A.& al-Jammal, Sarah S.. Homocysteine, folic acid and vitamin B12 levels in serum of epileptic children. The Egyptian Journal of Medical Human Genetics. 2012. Vol. 13, no. 3, pp.275-280.
https://search.emarefa.net/detail/BIM-313013
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 279-280
رقم السجل
BIM-313013
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر