Synthesis of some new thieno [3,2-e] thiazin derivatives

العناوين الأخرى

تحضير و دراسة خواص بعض مركبات ثيينو-ثيازين

مقدم أطروحة جامعية

al-Husayn, Imad al-Din Muhammad Hajj

مشرف أطروحة جامعية

Abu al-Halawah, Rajab

أعضاء اللجنة

Tashtoush, Hassan I.
al-Saduni, Haytham H.
al-Abadelah, Mustafa M.

الجامعة

جامعة آل البيت

الكلية

كلية العلوم

القسم الأكاديمي

قسم الكيمياء

دولة الجامعة

الأردن

الدرجة العلمية

ماجستير

تاريخ الدرجة العلمية

2010

الملخص الإنجليزي

-A new series of 2-alkyl/arylamino-6-chlorothieno[3,2-e]-1,3-thiazin-3-one (48a-c) derivatives were synthesized by intramolecular cyclization reaction of the deprotonated 2,5-dichloro-N-(alkyl/arylaminocarbonothioyl)thiophene-3-carboxamides (47a-d) upon heating.

The latter compounds were prepared via interaction of the deprotonated 2,5-dichloro-3-thiophenecarbonylamide (46) with alky/arylisothiocyanates.

The starting carboxylic acid amide were prepared by utilizing 2,5-dichlorothiophene-3-carboxylic acid chloride (42).

The latter acid chloride was prepared according to the reported procedure that involves the reaction of 2,5-dichlorothiophene (39) with acetyl chloride in carbon disulfide in the presence of aluminum trichloride, followed by treatment of the resulting 3-acetyl-2,5-dichlorothiophene (40) with sodium hypochlorite solution followed by acidification.

The acid was converted into 2,5-dichlorothiophene-3-carbonyl chloride (42) upon interaction with thionyl chloride . The structures of these new bicyclic derivatives and their acyclic precursors are based on micro analytical and spectral (IR, MS, and NMR) data.

التخصصات الرئيسية

الكيمياء

عدد الصفحات

84

قائمة المحتويات

• APA
• MLA
• AMA

لغة النص

الإنجليزية

نوع البيانات

رسائل جامعية

رقم السجل

BIM-314832