Study of inclusion complexes between prednisone and cyclodextrins by spectrophotometry and molecular mechanics
مقدم أطروحة جامعية
مشرف أطروحة جامعية
الجامعة
جامعة آل البيت
الكلية
كلية العلوم
القسم الأكاديمي
قسم الكيمياء
دولة الجامعة
الأردن
الدرجة العلمية
ماجستير
تاريخ الدرجة العلمية
2007
الملخص الإنجليزي
The objectives of this work are to study the complexation of prednisone with cyclodextrins and to get data about it, such as; its phase solubility diagram, changing in thermodynamic parameters, modeling …etc., and improving the solubility of prednisone.
Techniques used are constructing a phase solubility diagram, calculating thermodynamic parameters, through taking excess of drug versus different concentrations of cyclodextrins on different temperatures at equilibrium; prednisone and cyclodextrins; α, β, γ and HP-β-cyclodextrins, in buffer solutions of 0.1 M phosphoric acid and 0.1 M sodium chloride Neutralized to pH 7.1 by sodium hydroxide using double distilled water, on different temperatures : 25, 30, 37, 41, 45 o C for β-cyclodextrin and 25 o C for the others, using different concentrations of the cyclodextrins in every study.
constructing a model for Hyper hem 7.52 was done for calculating the best situations for complexes and theoretical calculations (thermodynamic parameters), then comparing theoretical and experimental results.
Complexes formations are studied by UV-Vis spectrophotometry, and with differential scanning calorimetry DSC to insure of their formation.
Phase solubility diagrams were plotted for every cyclodextrin type with prednisone, and so for each study was determined, and also solubility constants were calculated.
G0 (kJ / mol) S0 (J / molK) H0 (kJ / mol) Complex -20.7 S0 (J / molK) -38.05 Predv/CD The thermodynamic functions were determined through van's Hoff equation.
The study showed that formation of complexes between prednisone and cyclodextrin is driven by enthalpy factors.
Formation of complexes is favorable, calculations and simulation computer program approved that (Hyper Chem).
The solubility of prednisone increased by complexation on all temperatures study deal with, as an example ; at 37oC the concentration of prednisone before addition of β-CD was 0.71 mM, and after addition of β-CD improved to be 3.10 mM.
التخصصات الرئيسية
الموضوعات
عدد الصفحات
79
قائمة المحتويات
Table of contents.
Abstract.
Chapter One : introduction.
Chapter Two : theoretical approach.
Chapter Three : experimental part.
Chapter Four : results and discussion.
References.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ghazzali, Amir M. A.. (2007). Study of inclusion complexes between prednisone and cyclodextrins by spectrophotometry and molecular mechanics. (Master's theses Theses and Dissertations Master). Al albayt University, Jordan
https://search.emarefa.net/detail/BIM-314895
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ghazzali, Amir M. A.. Study of inclusion complexes between prednisone and cyclodextrins by spectrophotometry and molecular mechanics. (Master's theses Theses and Dissertations Master). Al albayt University. (2007).
https://search.emarefa.net/detail/BIM-314895
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ghazzali, Amir M. A.. (2007). Study of inclusion complexes between prednisone and cyclodextrins by spectrophotometry and molecular mechanics. (Master's theses Theses and Dissertations Master). Al albayt University, Jordan
https://search.emarefa.net/detail/BIM-314895
لغة النص
الإنجليزية
نوع البيانات
رسائل جامعية
رقم السجل
BIM-314895
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر