Synthesis, characterization, and biological activity of novel mixed ligand complexes of ZN(II)‎ naproxen with nitrogen based ligands

العناوين الأخرى

تحضير و تشخيص و دراسة الفعالية الحيوية لمركبات تحتوي أيون الزنك الثنائي و النبروكسين و قواعد نيتروجينية

مقدم أطروحة جامعية

Faris, Hadil Hassan

مشرف أطروحة جامعية

Abu Ali, Hijazi

أعضاء اللجنة

Awad, Hani
Abu Hijlah, Abd al-Latif

الجامعة

جامعة بيرزيت

الكلية

كلية العلوم

القسم الأكاديمي

دائرة الكيماء

دولة الجامعة

فلسطين (الضفة الغربية)

الدرجة العلمية

ماجستير

تاريخ الدرجة العلمية

2012

الملخص الإنجليزي

In this present work eleven novel Zn (II) complexes [Zn2 (nap) 4] (1), [Zn (nap) 21, 10-phen] (2) [Zn (nap) 22, 9-dmphen] (3), [Zn (nap) 22, 2-bipy] (4), [Zn(nap)2(2-ampy)2] (5), [Zn2(nap) 4 (4-pic) 2] (6), [Zn (nap) 24, 4-bipy] n (7), [Zn2 (nap) 4 (quin) 2] (8), [Zn (nap) 2 (imid) 2] (9), [Zn (nap) 2 (1, 2-dmimid) 2] (10), [Zn (nap) 2 (pyrazole) 2] (11) were synthesized and characterized by IR, UV-Vis, 1H NMR, 13C {1H} NMR spectroscopy.

X-ray crystallography for complex 3 was also determined.

In order to assess the effect of the metal ions on the anti-bacterial activity, the ligands and their complexes 1-11 have been screened in-vitro, against Gram positive, (G+) bacteria (Staphylococcus aureus and Micrococcus luteus) and Gram negative, (G-) bacteria (Klebsiella pneumoniae, Pseudomonas aeruginosa, Proteus mirabilis and Escherichia coli) using the agar well diffusion method.

All complexes exhibit anti-bacterial activity against the tested bacterial species except complex 8.

Due to the higher anti-bacterial activity of complexes 2, 3, 5 they were chosen and tested with their parent nitrogen donor ligands to determine the effect of the complexation on the anti-bacterial activity.

Complex 2 showed lower anti-bacterial activity against the tested bacterial species than the 1, 10-phenanthroline ligand, so in this complex the anti-bacterial activity decreased due to complexation.

Complex 3 showed higher anti-bacterial activity against G- bacteria than its parent ligand, 2, 9-dimethyl-1, 10-phenanthroline, but this ligand showed higher anti-bacterial activity against G+ than complex 3.

Complex 5 showed anti-bacterial activity only against G+, and 2-amino pyridine ligand did not show anti-bacterial activity against the tested bacterial species.

التخصصات الرئيسية

الأحياء

الموضوعات

• النيتروجين
• الزنك

عدد الصفحات

90

قائمة المحتويات

• APA
• MLA
• AMA

لغة النص

الإنجليزية

نوع البيانات

رسائل جامعية

رقم السجل

BIM-316154