Synthesis, characterization, and biological activity of novel mixed ligand complexes of ZN(II) naproxen with nitrogen based ligands
Other Title(s)
تحضير و تشخيص و دراسة الفعالية الحيوية لمركبات تحتوي أيون الزنك الثنائي و النبروكسين و قواعد نيتروجينية
Dissertant
Thesis advisor
Comitee Members
Awad, Hani
Abu Hijlah, Abd al-Latif
University
Birzeit University
Faculty
Faculty of Science
Department
Department of Chemistry
University Country
Palestine (West Bank)
Degree
Master
Degree Date
2012
English Abstract
In this present work eleven novel Zn (II) complexes [Zn2 (nap) 4] (1), [Zn (nap) 21, 10-phen] (2) [Zn (nap) 22, 9-dmphen] (3), [Zn (nap) 22, 2-bipy] (4), [Zn(nap)2(2-ampy)2] (5), [Zn2(nap) 4 (4-pic) 2] (6), [Zn (nap) 24, 4-bipy] n (7), [Zn2 (nap) 4 (quin) 2] (8), [Zn (nap) 2 (imid) 2] (9), [Zn (nap) 2 (1, 2-dmimid) 2] (10), [Zn (nap) 2 (pyrazole) 2] (11) were synthesized and characterized by IR, UV-Vis, 1H NMR, 13C {1H} NMR spectroscopy.
X-ray crystallography for complex 3 was also determined.
In order to assess the effect of the metal ions on the anti-bacterial activity, the ligands and their complexes 1-11 have been screened in-vitro, against Gram positive, (G+) bacteria (Staphylococcus aureus and Micrococcus luteus) and Gram negative, (G-) bacteria (Klebsiella pneumoniae, Pseudomonas aeruginosa, Proteus mirabilis and Escherichia coli) using the agar well diffusion method.
All complexes exhibit anti-bacterial activity against the tested bacterial species except complex 8.
Due to the higher anti-bacterial activity of complexes 2, 3, 5 they were chosen and tested with their parent nitrogen donor ligands to determine the effect of the complexation on the anti-bacterial activity.
Complex 2 showed lower anti-bacterial activity against the tested bacterial species than the 1, 10-phenanthroline ligand, so in this complex the anti-bacterial activity decreased due to complexation.
Complex 3 showed higher anti-bacterial activity against G- bacteria than its parent ligand, 2, 9-dimethyl-1, 10-phenanthroline, but this ligand showed higher anti-bacterial activity against G+ than complex 3.
Complex 5 showed anti-bacterial activity only against G+, and 2-amino pyridine ligand did not show anti-bacterial activity against the tested bacterial species.
Main Subjects
Topics
No. of Pages
90
Table of Contents
Table of contents.
Abstract.
Chapter One : introduction.
Chapter Two : aim of the research.
Chapter Three : experimental.
Chapter Four : results and discussion.
Chapter Five : conclusion.
References.
American Psychological Association (APA)
Faris, Hadil Hassan. (2012). Synthesis, characterization, and biological activity of novel mixed ligand complexes of ZN(II) naproxen with nitrogen based ligands. (Master's theses Theses and Dissertations Master). Birzeit University, Palestine (West Bank)
https://search.emarefa.net/detail/BIM-316154
Modern Language Association (MLA)
Faris, Hadil Hassan. Synthesis, characterization, and biological activity of novel mixed ligand complexes of ZN(II) naproxen with nitrogen based ligands. (Master's theses Theses and Dissertations Master). Birzeit University. (2012).
https://search.emarefa.net/detail/BIM-316154
American Medical Association (AMA)
Faris, Hadil Hassan. (2012). Synthesis, characterization, and biological activity of novel mixed ligand complexes of ZN(II) naproxen with nitrogen based ligands. (Master's theses Theses and Dissertations Master). Birzeit University, Palestine (West Bank)
https://search.emarefa.net/detail/BIM-316154
Language
English
Data Type
Arab Theses
Record ID
BIM-316154
