Genotyping of HLA-DQA1 and HLA-DQB1 antigens among patients with helicobacter pylori associated gastritis

العناوين الأخرى

دراسة جينية لمستضدات HLA-DQA1, HLA-DQB1 في المرضى المصابين بالتهاب المعدة المرتبط مع جرثومة helicobacter pylori

مقدم أطروحة جامعية

al-Ammar, Nibras Salim

مشرف أطروحة جامعية

al-Saimary, Ihsan
Hammadi, Sad Shahin

أعضاء اللجنة

Nimah, Jafar K.
Jibur, Muhammad Sh.
Aubaid, Adnan H.
Hashim, Ali R.
al-Bakri, Sundus Abd al-Abbas Abd Allah

الجامعة

جامعة البصرة

الكلية

كلية الطب

القسم الأكاديمي

قسم الأحياء المجهرية

دولة الجامعة

العراق

الدرجة العلمية

دكتوراه

تاريخ الدرجة العلمية

2010

الملخص الإنجليزي

The present study was carried out during the period from (17th of April 2009 to 15th of July 2010).

Out of 100 patients with various gastritis symptoms and underwent upper gastrointestinal endoscopic examination, 70 (70 %) showed abnormal endoscopic findings ; 29 (41 %) males and 41 (58.57 %) females, while 30 (30 %) showed normal endoscopic examination ; 12 (40 %) males and 18 (60 %) females.

A total of 30 healthy controls (18 males and 12 females), with age groups from (15-61) years, without any symptoms of gastritis, were selected randomly.

Out of 70 patients, 55 (79 %) were diagnosed as acute gastritis and 15 (21 %) as chronic gastritis.

The presence of association with H.

pylori was determined by biopsy rapid urease test and rapid diagnostic test.

Out of 70 gastritis patients, 52 (74.29 %) were positive rapid urease test (RUT) and 61 (87.14 %) were positive rapid diagnostic test (RDT).

DQA1 and DQB1 alleles frequencies were studied in 70 H.

pylori associated gastritis patients and 30 healthy controls.

DQA1 * 0201 decreased allele frequency was statistically not significant in H.

pylori associated gastritis patients, but there was a strong association (odds ratio = 2.61 (, as compared with controls.

DQB1 * 060101 allele frequency was statistically not significant in H.

pylori associated gastritis patients, but there was a strong association (odds ratio = 3.44), as compared with controls.

A significant decreased frequency of DQA1 * 0201 allele was found in individuals (patients + controls) with family history of gastritis with a strong association (odds ratio = 4.57), as compared with individuals without family history of gastritis.

Significant increased alleles frequencies of DQA1 * 0402 and DQB1 * 0402 were found in individuals with family history of gastritis, but with weak association (odds ratios, 0.16 and 0.20 respectively), as compared with individuals without family history of gastritis.

Significant increased frequencies of DQB1*050101 and DQB1 * 050201 alleles were found in gastritis patients who showed (+ RUT), but with weak association (odds ratios were 0.83 and 0.79 respectively), as compared with gastritis patients who showed (- RUT).

A significant increased frequency of DQA1 * 050101 allele was found in individuals (patients + controls) who showed (+RDT), but the association was weak (odds ratio = 0.39), as compared with individuals (patients + controls) with (- RDT).

A significant increased frequency of DQB1 * 020101 allele was found in individuals (patients + controls) with (+RDT), but the association was weak (odds ratio = 0.33), as compared with individuals (patients + controls) with (- RDT).

A significant decreased frequency of DQB1 * 050201 allele was found in individuals (patients + controls) with (+RDT).

The association was very strong (odds ratio = 5.31), as compared with individuals (patients + controls) with (- RDT).

A significant decreased frequencies of DQA1*0201 and DQB1 * 020101 alleles were found in gastritis patients with (+RDT).

The association in DQA1*0201 was very strong (odds ratio = 6.38) and for -DQB1 * 020101 allele, the association was weak (odds ratio = 0.08), as compared with controls with (+ RDT).

A significant increased frequency of DQA1 * 0201 allele was found in controls with (+ RDT) and the association was very strong (odds ratio = 6.18), as compared with controls with (- RDT).

A significant increased frequency of DQB1 * 020101 allele was found in controls with (+RDT) but with weak association (odds ratio = 0.09), as compared with controls with (- RDT).

التخصصات الرئيسية

الأحياء
الطب البشري

الموضوعات

• الجهاز الهضمي
• الأمراض
• التهاب المعدة
• الالتهاب

عدد الصفحات

172

قائمة المحتويات

• APA
• MLA
• AMA

لغة النص

الإنجليزية

نوع البيانات

رسائل جامعية

رقم السجل

BIM-316918