Genotyping of HLA-DQA1 and HLA-DQB1 antigens among patients with helicobacter pylori associated gastritis
Other Title(s)
دراسة جينية لمستضدات HLA-DQA1, HLA-DQB1 في المرضى المصابين بالتهاب المعدة المرتبط مع جرثومة helicobacter pylori
Dissertant
Thesis advisor
al-Saimary, Ihsan
Hammadi, Sad Shahin
Comitee Members
Nimah, Jafar K.
Jibur, Muhammad Sh.
Aubaid, Adnan H.
Hashim, Ali R.
al-Bakri, Sundus Abd al-Abbas Abd Allah
University
University of Basrah
Faculty
Medicine College
Department
Department of Microbiology
University Country
Iraq
Degree
Ph.D.
Degree Date
2010
English Abstract
The present study was carried out during the period from (17th of April 2009 to 15th of July 2010).
Out of 100 patients with various gastritis symptoms and underwent upper gastrointestinal endoscopic examination, 70 (70 %) showed abnormal endoscopic findings ; 29 (41 %) males and 41 (58.57 %) females, while 30 (30 %) showed normal endoscopic examination ; 12 (40 %) males and 18 (60 %) females.
A total of 30 healthy controls (18 males and 12 females), with age groups from (15-61) years, without any symptoms of gastritis, were selected randomly.
Out of 70 patients, 55 (79 %) were diagnosed as acute gastritis and 15 (21 %) as chronic gastritis.
The presence of association with H.
pylori was determined by biopsy rapid urease test and rapid diagnostic test.
Out of 70 gastritis patients, 52 (74.29 %) were positive rapid urease test (RUT) and 61 (87.14 %) were positive rapid diagnostic test (RDT).
DQA1 and DQB1 alleles frequencies were studied in 70 H.
pylori associated gastritis patients and 30 healthy controls.
DQA1 * 0201 decreased allele frequency was statistically not significant in H.
pylori associated gastritis patients, but there was a strong association (odds ratio = 2.61 (, as compared with controls.
DQB1 * 060101 allele frequency was statistically not significant in H.
pylori associated gastritis patients, but there was a strong association (odds ratio = 3.44), as compared with controls.
A significant decreased frequency of DQA1 * 0201 allele was found in individuals (patients + controls) with family history of gastritis with a strong association (odds ratio = 4.57), as compared with individuals without family history of gastritis.
Significant increased alleles frequencies of DQA1 * 0402 and DQB1 * 0402 were found in individuals with family history of gastritis, but with weak association (odds ratios, 0.16 and 0.20 respectively), as compared with individuals without family history of gastritis.
Significant increased frequencies of DQB1*050101 and DQB1 * 050201 alleles were found in gastritis patients who showed (+ RUT), but with weak association (odds ratios were 0.83 and 0.79 respectively), as compared with gastritis patients who showed (- RUT).
A significant increased frequency of DQA1 * 050101 allele was found in individuals (patients + controls) who showed (+RDT), but the association was weak (odds ratio = 0.39), as compared with individuals (patients + controls) with (- RDT).
A significant increased frequency of DQB1 * 020101 allele was found in individuals (patients + controls) with (+RDT), but the association was weak (odds ratio = 0.33), as compared with individuals (patients + controls) with (- RDT).
A significant decreased frequency of DQB1 * 050201 allele was found in individuals (patients + controls) with (+RDT).
The association was very strong (odds ratio = 5.31), as compared with individuals (patients + controls) with (- RDT).
A significant decreased frequencies of DQA1*0201 and DQB1 * 020101 alleles were found in gastritis patients with (+RDT).
The association in DQA1*0201 was very strong (odds ratio = 6.38) and for -DQB1 * 020101 allele, the association was weak (odds ratio = 0.08), as compared with controls with (+ RDT).
A significant increased frequency of DQA1 * 0201 allele was found in controls with (+ RDT) and the association was very strong (odds ratio = 6.18), as compared with controls with (- RDT).
A significant increased frequency of DQB1 * 020101 allele was found in controls with (+RDT) but with weak association (odds ratio = 0.09), as compared with controls with (- RDT).
Main Subjects
Topics
No. of Pages
172
Table of Contents
Table of contents.
Abstract.
Chapter One.
Chapter Two : literature review.
Chapter Three : materials and methods.
Chapter Four : results.
Chapter Five : discussion.
Conclusions and recommendations.
References.
American Psychological Association (APA)
al-Ammar, Nibras Salim. (2010). Genotyping of HLA-DQA1 and HLA-DQB1 antigens among patients with helicobacter pylori associated gastritis. (Doctoral dissertations Theses and Dissertations Master). University of Basrah, Iraq
https://search.emarefa.net/detail/BIM-316918
Modern Language Association (MLA)
al-Ammar, Nibras Salim. Genotyping of HLA-DQA1 and HLA-DQB1 antigens among patients with helicobacter pylori associated gastritis. (Doctoral dissertations Theses and Dissertations Master). University of Basrah. (2010).
https://search.emarefa.net/detail/BIM-316918
American Medical Association (AMA)
al-Ammar, Nibras Salim. (2010). Genotyping of HLA-DQA1 and HLA-DQB1 antigens among patients with helicobacter pylori associated gastritis. (Doctoral dissertations Theses and Dissertations Master). University of Basrah, Iraq
https://search.emarefa.net/detail/BIM-316918
Language
English
Data Type
Arab Theses
Record ID
BIM-316918
