Evaluation of the antibacterial activity of newly-synthesized substituted 4-oxo-thiazolidine compounds

العناوين الأخرى

تقييم الفعالية المضادة للبكتيريا لمركب جديد من الثيازولدين

الجامعة

جامعة آل البيت

الكلية

كلية العلوم

القسم الأكاديمي

قسم العلوم الحياتية

دولة الجامعة

الأردن

الدرجة العلمية

ماجستير

تاريخ الدرجة العلمية

2012

الملخص الإنجليزي

This study is interested in evaluating the antibacterial activity of newly synthesized 4- oxo-thiazolidine compounds against different Gram-positive and Gram-negative bacteria.

The new thiazolidine compounds were previously synthesized and characterized by Elian (2007) in the department of Chemistry, Yarmouk University and used in this current investigation.

The compounds were tested against three types of bacteria: standard bacterial strains, environmental bacterial strains, and clinical bacterial strains.

Members of the latter group of bacteria were isolated from clinical samples and identified by biochemical method as well as molecular method (16S rRNA gene sequencing).

These biochemical and molecular analyses led for the isolation of three novel bacterial strains and one bacterial species.

The antibacterial activity of the new 4-oxo-thiazolidines, carried out by agar well diffusion method and broth dilution method, showed that all compounds were active against different bacterial species.

Some compounds were more active against the clinical bacterial isolates than the positive control (cloxacillin, a P-lactam antibiotic).

The most prominent activities were detected in case of the compounds T2 and T3, against the clinical isolate Pseudomonas aeruginosa (SSI), as well as the compound T5 against Staphylococcus epidermidis (SS4).

Therefore, further studies must be carried out to test the toxicity of these compounds and the feasibility of these compounds to be used in the future as antibacterial agents against clinical isolates as well as against other types of microorganisms such as fungi and protozoa.

التخصصات الرئيسية

الأحياء

الموضوعات

عدد الصفحات

قائمة المحتويات

Table of contents.

Abstract.

Abstract in Arabic.

Chapter One : introduction.

Chapter Two : material and methods.

Chapter Three : results.

Chapter Four : discussion.

conclusion and recommendation.

References.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

al-Masaid, Salamah Hamdan. (2012). Evaluation of the antibacterial activity of newly-synthesized substituted 4-oxo-thiazolidine compounds. (Master's theses Theses and Dissertations Master). Al albayt University, Jordan
https://search.emarefa.net/detail/BIM-321695

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

al-Masaid, Salamah Hamdan. Evaluation of the antibacterial activity of newly-synthesized substituted 4-oxo-thiazolidine compounds. (Master's theses Theses and Dissertations Master). Al albayt University. (2012).
https://search.emarefa.net/detail/BIM-321695

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

لغة النص

الإنجليزية

نوع البيانات

رسائل جامعية

رقم السجل

BIM-321695

حفظتم الحفظ طباعة

قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"

أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي

منصة "معرفة" للكتاب العربي الجامعي الرقمي

تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر