Evaluation of the antibacterial activity of newly-synthesized substituted 4-oxo-thiazolidine compounds
Other Title(s)
تقييم الفعالية المضادة للبكتيريا لمركب جديد من الثيازولدين
Dissertant
Thesis advisor
Comitee Members
al-Suud, Yasin Ahmad
Husayn, Imad Ahmad
al-Fawwaz, Abd Allah
University
Al albayt University
Faculty
Faculty of Sciences
Department
Department of Biological Sciences
University Country
Jordan
Degree
Master
Degree Date
2012
English Abstract
This study is interested in evaluating the antibacterial activity of newly synthesized 4- oxo-thiazolidine compounds against different Gram-positive and Gram-negative bacteria.
The new thiazolidine compounds were previously synthesized and characterized by Elian (2007) in the department of Chemistry, Yarmouk University and used in this current investigation.
The compounds were tested against three types of bacteria: standard bacterial strains, environmental bacterial strains, and clinical bacterial strains.
Members of the latter group of bacteria were isolated from clinical samples and identified by biochemical method as well as molecular method (16S rRNA gene sequencing).
These biochemical and molecular analyses led for the isolation of three novel bacterial strains and one bacterial species.
The antibacterial activity of the new 4-oxo-thiazolidines, carried out by agar well diffusion method and broth dilution method, showed that all compounds were active against different bacterial species.
Some compounds were more active against the clinical bacterial isolates than the positive control (cloxacillin, a P-lactam antibiotic).
The most prominent activities were detected in case of the compounds T2 and T3, against the clinical isolate Pseudomonas aeruginosa (SSI), as well as the compound T5 against Staphylococcus epidermidis (SS4).
Therefore, further studies must be carried out to test the toxicity of these compounds and the feasibility of these compounds to be used in the future as antibacterial agents against clinical isolates as well as against other types of microorganisms such as fungi and protozoa.
Main Subjects
Topics
No. of Pages
51
Table of Contents
Table of contents.
Abstract.
Abstract in Arabic.
Chapter One : introduction.
Chapter Two : material and methods.
Chapter Three : results.
Chapter Four : discussion.
conclusion and recommendation.
References.
American Psychological Association (APA)
al-Masaid, Salamah Hamdan. (2012). Evaluation of the antibacterial activity of newly-synthesized substituted 4-oxo-thiazolidine compounds. (Master's theses Theses and Dissertations Master). Al albayt University, Jordan
https://search.emarefa.net/detail/BIM-321695
Modern Language Association (MLA)
al-Masaid, Salamah Hamdan. Evaluation of the antibacterial activity of newly-synthesized substituted 4-oxo-thiazolidine compounds. (Master's theses Theses and Dissertations Master). Al albayt University. (2012).
https://search.emarefa.net/detail/BIM-321695
American Medical Association (AMA)
al-Masaid, Salamah Hamdan. (2012). Evaluation of the antibacterial activity of newly-synthesized substituted 4-oxo-thiazolidine compounds. (Master's theses Theses and Dissertations Master). Al albayt University, Jordan
https://search.emarefa.net/detail/BIM-321695
Language
English
Data Type
Arab Theses
Record ID
BIM-321695
