Basiliximab induction in renal transplantation : long-term outcome
المؤلفون المشاركون
Atlani, Mahendra
Sharma, Raj K.
Gupta, Amit
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 24، العدد 3 (30 يونيو/حزيران 2013)، ص ص. 473-479، 7ص.
الناشر
تاريخ النشر
2013-06-30
دولة النشر
السعودية
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
الملخص EN
Anti-IL-2 receptor has been proven to be effective in reducing the rate of acute rejection in kidney transplantation and also in improving the graft and patient survival rates.
In this study, we retrospectively reviewed the role of the anti-IL-2 receptor, basiliximab, as an induction immunosuppression.
Fifty-seven kidney transplant recipients from living donors who received the IL-2 blocker basiliximab (Group 1) as induction therapy in combination with cyclosporine (CsA), steroids and mycophenolate mofetil (MMF) or azathioprine (AZA) were compared with similarly matched renal transplant recipients (N = 312) who did not receive induction therapy (Group 2).
Survival analysis was performed using the Kaplan-Meir method.
Chi-square test was used to compare the outcome difference of various parameters between the two groups.
Both the groups were similar in terms of demographic charateristcs and maintenance immunosuppression used.
The total number of rejections was significantly less in Group 1, 14 % vs 25 % in Group 2 (P = 0.04, Odds ratio = 0.44).
A higher number of patients in Group 2 had steroid-resistant rejections, although the difference was not statistically significant (9.9 % in Group 2 vs 5.3 % in Group 1).
Death-censored graft survival was not significantly better in Group 1 at five years as compared with Group 2 (79.4 % vs 47.2 %, P = 0.09).
On multivariate analysis for association with graft survival, only late acute rejections and steroid-resistant rejections were independently associated with poor graft survival, while the type of maintenance immuno-suppression (MMF vs AZA), use of basiliximab induction therapy and total number of acute rejection episodes had no association.
Our study suggests that the use of anti-IL-2 receptor antibody basiliximab as induction immuno-suppression results in significantly better prevention of acute rejection, but it does not result in a significantly improved graft survival at five years.
It also results in reduced severity of acute rejection.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Atlani, Mahendra& Sharma, Raj K.& Gupta, Amit. 2013. Basiliximab induction in renal transplantation : long-term outcome. Saudi Journal of Kidney Diseases and Transplantation،Vol. 24, no. 3, pp.473-479.
https://search.emarefa.net/detail/BIM-328436
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Atlani, Mahendra…[et al.]. Basiliximab induction in renal transplantation : long-term outcome. Saudi Journal of Kidney Diseases and Transplantation Vol. 24, no. 3 (Jun. 2013), pp.473-479.
https://search.emarefa.net/detail/BIM-328436
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Atlani, Mahendra& Sharma, Raj K.& Gupta, Amit. Basiliximab induction in renal transplantation : long-term outcome. Saudi Journal of Kidney Diseases and Transplantation. 2013. Vol. 24, no. 3, pp.473-479.
https://search.emarefa.net/detail/BIM-328436
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 478-479
رقم السجل
BIM-328436
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر