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Basiliximab induction in renal transplantation : long-term outcome
Joint Authors
Atlani, Mahendra
Sharma, Raj K.
Gupta, Amit
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 24, Issue 3 (30 Jun. 2013), pp.473-479, 7 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2013-06-30
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Topics
Abstract EN
Anti-IL-2 receptor has been proven to be effective in reducing the rate of acute rejection in kidney transplantation and also in improving the graft and patient survival rates.
In this study, we retrospectively reviewed the role of the anti-IL-2 receptor, basiliximab, as an induction immunosuppression.
Fifty-seven kidney transplant recipients from living donors who received the IL-2 blocker basiliximab (Group 1) as induction therapy in combination with cyclosporine (CsA), steroids and mycophenolate mofetil (MMF) or azathioprine (AZA) were compared with similarly matched renal transplant recipients (N = 312) who did not receive induction therapy (Group 2).
Survival analysis was performed using the Kaplan-Meir method.
Chi-square test was used to compare the outcome difference of various parameters between the two groups.
Both the groups were similar in terms of demographic charateristcs and maintenance immunosuppression used.
The total number of rejections was significantly less in Group 1, 14 % vs 25 % in Group 2 (P = 0.04, Odds ratio = 0.44).
A higher number of patients in Group 2 had steroid-resistant rejections, although the difference was not statistically significant (9.9 % in Group 2 vs 5.3 % in Group 1).
Death-censored graft survival was not significantly better in Group 1 at five years as compared with Group 2 (79.4 % vs 47.2 %, P = 0.09).
On multivariate analysis for association with graft survival, only late acute rejections and steroid-resistant rejections were independently associated with poor graft survival, while the type of maintenance immuno-suppression (MMF vs AZA), use of basiliximab induction therapy and total number of acute rejection episodes had no association.
Our study suggests that the use of anti-IL-2 receptor antibody basiliximab as induction immuno-suppression results in significantly better prevention of acute rejection, but it does not result in a significantly improved graft survival at five years.
It also results in reduced severity of acute rejection.
American Psychological Association (APA)
Atlani, Mahendra& Sharma, Raj K.& Gupta, Amit. 2013. Basiliximab induction in renal transplantation : long-term outcome. Saudi Journal of Kidney Diseases and Transplantation،Vol. 24, no. 3, pp.473-479.
https://search.emarefa.net/detail/BIM-328436
Modern Language Association (MLA)
Atlani, Mahendra…[et al.]. Basiliximab induction in renal transplantation : long-term outcome. Saudi Journal of Kidney Diseases and Transplantation Vol. 24, no. 3 (Jun. 2013), pp.473-479.
https://search.emarefa.net/detail/BIM-328436
American Medical Association (AMA)
Atlani, Mahendra& Sharma, Raj K.& Gupta, Amit. Basiliximab induction in renal transplantation : long-term outcome. Saudi Journal of Kidney Diseases and Transplantation. 2013. Vol. 24, no. 3, pp.473-479.
https://search.emarefa.net/detail/BIM-328436
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 478-479
Record ID
BIM-328436