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The comparative effects of atorvastatin and quince leaf extract on atherosclerosis
المؤلفون المشاركون
Khademi, Farzaneh
Danesh, Behnam
Nejad, Daruosh Muhammad
Rad, Jafar Sulaymani
المصدر
Iranian Red Crescent Medical Journal
العدد
المجلد 15، العدد 8 (31 أغسطس/آب 2013)14ص.
الناشر
تاريخ النشر
2013-08-31
دولة النشر
الإمارات العربية المتحدة
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Background : this study investigates the ability of quince leaf extract to prevent progression of atherosclerosis and to determine the lipid-lowering effect of it.
Objectives : this study suggested that quince leaf effects on progression of atherosclerosis, and performed comparison with atorvastatin as a standard medication.
Materials and Methods : the effect of 50 mg / kg of the quince leaf extract on lipid profiles was assessed by measuring the levels of totalcholesterol, triglyceride, LDL, HDL, and liver enzymes (AST, ALT, and AP) in plasma and were evaluated the thickness of aortic plaques in the hypercholesterolemic rabbits after stopping.
These assessments were performed using 0.5 mg/kg of atorvastatin.
Results : oral administration of cholesterol for 8 weeks resulted in a significant increase (P < 0.05) in plasma markers.
Treatment with the extract at dose of 50 mg / kg and 0.5 mg / kg of atorvastatin not only were reduced lipid profile in plasma (P < 0.05) but also were increased HDL-cholesterol levels.
There were decrease (P = 0.04) in the liver enzymes in extract treated rabbits.
However, plaque thickness had no significant difference in the aorta of treated rabbits compared with studied control.
Conclusions : these results indicate the lipid-lowering effects of quince leaf similar to atorvastatin and it can probably serve as a new potential natural product for atherosclerosis treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Khademi, Farzaneh& Danesh, Behnam& Nejad, Daruosh Muhammad& Rad, Jafar Sulaymani. 2013. The comparative effects of atorvastatin and quince leaf extract on atherosclerosis. Iranian Red Crescent Medical Journal،Vol. 15, no. 8.
https://search.emarefa.net/detail/BIM-334397
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Khademi, Farzaneh…[et al.]. The comparative effects of atorvastatin and quince leaf extract on atherosclerosis. Iranian Red Crescent Medical Journal Vol. 15, no. 8 (Aug. 2013).
https://search.emarefa.net/detail/BIM-334397
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Khademi, Farzaneh& Danesh, Behnam& Nejad, Daruosh Muhammad& Rad, Jafar Sulaymani. The comparative effects of atorvastatin and quince leaf extract on atherosclerosis. Iranian Red Crescent Medical Journal. 2013. Vol. 15, no. 8.
https://search.emarefa.net/detail/BIM-334397
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-334397
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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