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The comparative effects of atorvastatin and quince leaf extract on atherosclerosis
Joint Authors
Khademi, Farzaneh
Danesh, Behnam
Nejad, Daruosh Muhammad
Rad, Jafar Sulaymani
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 15, Issue 8 (31 Aug. 2013)14 p.
Publisher
Publication Date
2013-08-31
Country of Publication
United Arab Emirates
No. of Pages
14
Main Subjects
Abstract EN
Background : this study investigates the ability of quince leaf extract to prevent progression of atherosclerosis and to determine the lipid-lowering effect of it.
Objectives : this study suggested that quince leaf effects on progression of atherosclerosis, and performed comparison with atorvastatin as a standard medication.
Materials and Methods : the effect of 50 mg / kg of the quince leaf extract on lipid profiles was assessed by measuring the levels of totalcholesterol, triglyceride, LDL, HDL, and liver enzymes (AST, ALT, and AP) in plasma and were evaluated the thickness of aortic plaques in the hypercholesterolemic rabbits after stopping.
These assessments were performed using 0.5 mg/kg of atorvastatin.
Results : oral administration of cholesterol for 8 weeks resulted in a significant increase (P < 0.05) in plasma markers.
Treatment with the extract at dose of 50 mg / kg and 0.5 mg / kg of atorvastatin not only were reduced lipid profile in plasma (P < 0.05) but also were increased HDL-cholesterol levels.
There were decrease (P = 0.04) in the liver enzymes in extract treated rabbits.
However, plaque thickness had no significant difference in the aorta of treated rabbits compared with studied control.
Conclusions : these results indicate the lipid-lowering effects of quince leaf similar to atorvastatin and it can probably serve as a new potential natural product for atherosclerosis treatment.
American Psychological Association (APA)
Khademi, Farzaneh& Danesh, Behnam& Nejad, Daruosh Muhammad& Rad, Jafar Sulaymani. 2013. The comparative effects of atorvastatin and quince leaf extract on atherosclerosis. Iranian Red Crescent Medical Journal،Vol. 15, no. 8.
https://search.emarefa.net/detail/BIM-334397
Modern Language Association (MLA)
Khademi, Farzaneh…[et al.]. The comparative effects of atorvastatin and quince leaf extract on atherosclerosis. Iranian Red Crescent Medical Journal Vol. 15, no. 8 (Aug. 2013).
https://search.emarefa.net/detail/BIM-334397
American Medical Association (AMA)
Khademi, Farzaneh& Danesh, Behnam& Nejad, Daruosh Muhammad& Rad, Jafar Sulaymani. The comparative effects of atorvastatin and quince leaf extract on atherosclerosis. Iranian Red Crescent Medical Journal. 2013. Vol. 15, no. 8.
https://search.emarefa.net/detail/BIM-334397
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-334397