Characterization of lymphocyte subsets as a tool of assessment of histological disease activity pattern in ulcerative colitis
المؤلف
المصدر
Journal of the Faculty of Medicine Baghdad
العدد
المجلد 52، العدد 3 (30 سبتمبر/أيلول 2010)، ص ص. 306-310، 5ص.
الناشر
تاريخ النشر
2010-09-30
دولة النشر
العراق
عدد الصفحات
5
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : In Ulcerative colitis (UC), the presence of a persistently elevated number of T cells in the inflamed area with respect to the activity of the disease suggesting bad prognosis.
This study was done to evaluate cellular immune response in different disease activity patterns and its possible implication in evaluation of disease activity.
Materials and methods : This study included Forty seven archived paraffin-embedded samples of ulcerative colitis ; these samples diagnosed and graded for disease activity.
Then dual immunofluorescence staining was used for phenotyping of lymphocytic infiltrate (CD3-CD19) and (CD4-CD8).
A total and differential T cell as well as plasma cell count was recorded in these UC tissue samples.
Non parametric Kruskal-Wallis test was used to compare the median cell counts among different study groups.
Results : There is higher lymphocytic infiltrate for all types of cells when UC samples compared with control samples with highly statistical significant difference, T cells represents the major constituents of colonic mucosal infiltrate (86.89 %) and about 75.79 % were CD4 positive T cells.
T-cell subsets and plasma cell have high statistical significant difference (p ≤ 0.001) according to histological grade.
Furthermore, with the histological grade the highest association found with T lymphocytes (r = 0.944) followed by T helper (r = 0.821), T cytotoxic (r = 0.653) and B lymphocyte (r = 0.237).
Conclusions : Qualitative and semi quantitative characterization of lymphocytes subsets was useful in the assessment of different histological grades of UC disease activity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ghazi, Haydar F.. 2010. Characterization of lymphocyte subsets as a tool of assessment of histological disease activity pattern in ulcerative colitis. Journal of the Faculty of Medicine Baghdad،Vol. 52, no. 3, pp.306-310.
https://search.emarefa.net/detail/BIM-335863
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ghazi, Haydar F.. Characterization of lymphocyte subsets as a tool of assessment of histological disease activity pattern in ulcerative colitis. Journal of the Faculty of Medicine Baghdad Vol. 52, no. 3 (2010), pp.306-310.
https://search.emarefa.net/detail/BIM-335863
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ghazi, Haydar F.. Characterization of lymphocyte subsets as a tool of assessment of histological disease activity pattern in ulcerative colitis. Journal of the Faculty of Medicine Baghdad. 2010. Vol. 52, no. 3, pp.306-310.
https://search.emarefa.net/detail/BIM-335863
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 309-310
رقم السجل
BIM-335863
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر