Chromosomal analysis and maternal age risk in some down syndrome patients

الملخص EN

Chromosomal analysis was done on 50 clinically diagnosed Down syndrome patients.

The karyotype analysis revealed that 88 % (44 of 50 cases) with trisomy 21, having three copies of chromosome 21.

In 2 % (one case) translocation was observed, one copy of chromosome 21 was translocated to another chromosome 21 and in 10 % (5 cases) there was a mosaicism for a trisomic.

The higher percentage (72 %) of cases was found between 21-34 years.

26 % of cases were found with ages above 35 years.

Only 2 % of cases were found with maternal age between18-20 years and Down syndrome is more frequent in males than in females.