Spectrophotometric method for the determination of captopril in pharmaceutical formulations

الملخص EN

A simple, rapid and sensitive spectrophotometric method has been developed for the determination of captopril in aqueous solution.

The method is based on reaction of captopril with 2, 3-dichloro 1, 4- naphthoquinon(Dichlone) in neutral medium to form a stable yellow colored product which shows maximum absorption at 347 nm with molar absorptivity of 5.6 ×103 L.mole-1.

cm-1.

The proposed method is applied successfully for determination of captopril in commercial pharmaceutical tablets.