Synthesis and in vitro biology of Co (II), Ni (II), Cu (II) and Zinc (II) complexes of functionalized beta-diketone bearing energy buried potential antibacterial and antiviral O, O pharmacophore sites
المؤلفون المشاركون
Juneja, Harjeet
Ali, Parvez
Ingle, Vishwas
Shaykh, Javed
Bin Haddad, Tayyib
المصدر
Journal of Saudi Chemical Society
العدد
المجلد 17، العدد 3 (31 يوليو/تموز 2013)، ص ص. 269-276، 8ص.
الناشر
تاريخ النشر
2013-07-31
دولة النشر
السعودية
عدد الصفحات
8
التخصصات الرئيسية
الموضوعات
الملخص EN
The clinically active functionalized b-diketones 1- (20, 40-dihydroxyphenyl)-3-(200-substitutedphenyl)propane-1, 3-dione (L1)–(L2) have been synthesized from Baker–Venkataraman transformation of 2, 4-diaroyloxyacetophenones.
Their transition metal complexes (1)–(8) have been prepared and characterized by physical, spectral and analytical data.
The functionalized beta-diketone potentially acts as bidentate ligand and co-ordinate with the transition metal atom through beta-diketo system.
The complexes have general formula [ML2] where M =Co (II), Ni (II), Cu (II), Zinc (II) and L = ligand.
The 1-(20, 40-dihydroxyphenyl)-3-(200-substitutedphenyl)-propane-1, 3-dione and their transition metal complexes have been screened for in vitro antibacterial, antifungal and antioxidant bioassay.
The biological activity data show that the transition metal complexes are more potent antibacterial, antifungal and antioxidant agents than the parent functionalized betadiketone against different bacterial and fungal species.
This constitutes a new group of compounds that can be used as potential metal derived drugs.
Ultimately, here we can prompt about the use of metals for the drugs.
The metal complexes were also studied for their thermo gravimetric analyses.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shaykh, Javed& Juneja, Harjeet& Ingle, Vishwas& Ali, Parvez& Bin Haddad, Tayyib. 2013. Synthesis and in vitro biology of Co (II), Ni (II), Cu (II) and Zinc (II) complexes of functionalized beta-diketone bearing energy buried potential antibacterial and antiviral O, O pharmacophore sites. Journal of Saudi Chemical Society،Vol. 17, no. 3, pp.269-276.
https://search.emarefa.net/detail/BIM-351668
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shaykh, Javed…[et al.]. Synthesis and in vitro biology of Co (II), Ni (II), Cu (II) and Zinc (II) complexes of functionalized beta-diketone bearing energy buried potential antibacterial and antiviral O, O pharmacophore sites. Journal of Saudi Chemical Society Vol. 17, no. 3 (Jul. 2013), pp.269-276.
https://search.emarefa.net/detail/BIM-351668
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shaykh, Javed& Juneja, Harjeet& Ingle, Vishwas& Ali, Parvez& Bin Haddad, Tayyib. Synthesis and in vitro biology of Co (II), Ni (II), Cu (II) and Zinc (II) complexes of functionalized beta-diketone bearing energy buried potential antibacterial and antiviral O, O pharmacophore sites. Journal of Saudi Chemical Society. 2013. Vol. 17, no. 3, pp.269-276.
https://search.emarefa.net/detail/BIM-351668
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 276
رقم السجل
BIM-351668
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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