Synthesis and in vitro biology of Co (II), Ni (II), Cu (II) and Zinc (II) complexes of functionalized beta-diketone bearing energy buried potential antibacterial and antiviral O, O pharmacophore sites
Joint Authors
Juneja, Harjeet
Ali, Parvez
Ingle, Vishwas
Shaykh, Javed
Bin Haddad, Tayyib
Source
Journal of Saudi Chemical Society
Issue
Vol. 17, Issue 3 (31 Jul. 2013), pp.269-276, 8 p.
Publisher
Publication Date
2013-07-31
Country of Publication
Saudi Arabia
No. of Pages
8
Main Subjects
Topics
Abstract EN
The clinically active functionalized b-diketones 1- (20, 40-dihydroxyphenyl)-3-(200-substitutedphenyl)propane-1, 3-dione (L1)–(L2) have been synthesized from Baker–Venkataraman transformation of 2, 4-diaroyloxyacetophenones.
Their transition metal complexes (1)–(8) have been prepared and characterized by physical, spectral and analytical data.
The functionalized beta-diketone potentially acts as bidentate ligand and co-ordinate with the transition metal atom through beta-diketo system.
The complexes have general formula [ML2] where M =Co (II), Ni (II), Cu (II), Zinc (II) and L = ligand.
The 1-(20, 40-dihydroxyphenyl)-3-(200-substitutedphenyl)-propane-1, 3-dione and their transition metal complexes have been screened for in vitro antibacterial, antifungal and antioxidant bioassay.
The biological activity data show that the transition metal complexes are more potent antibacterial, antifungal and antioxidant agents than the parent functionalized betadiketone against different bacterial and fungal species.
This constitutes a new group of compounds that can be used as potential metal derived drugs.
Ultimately, here we can prompt about the use of metals for the drugs.
The metal complexes were also studied for their thermo gravimetric analyses.
American Psychological Association (APA)
Shaykh, Javed& Juneja, Harjeet& Ingle, Vishwas& Ali, Parvez& Bin Haddad, Tayyib. 2013. Synthesis and in vitro biology of Co (II), Ni (II), Cu (II) and Zinc (II) complexes of functionalized beta-diketone bearing energy buried potential antibacterial and antiviral O, O pharmacophore sites. Journal of Saudi Chemical Society،Vol. 17, no. 3, pp.269-276.
https://search.emarefa.net/detail/BIM-351668
Modern Language Association (MLA)
Shaykh, Javed…[et al.]. Synthesis and in vitro biology of Co (II), Ni (II), Cu (II) and Zinc (II) complexes of functionalized beta-diketone bearing energy buried potential antibacterial and antiviral O, O pharmacophore sites. Journal of Saudi Chemical Society Vol. 17, no. 3 (Jul. 2013), pp.269-276.
https://search.emarefa.net/detail/BIM-351668
American Medical Association (AMA)
Shaykh, Javed& Juneja, Harjeet& Ingle, Vishwas& Ali, Parvez& Bin Haddad, Tayyib. Synthesis and in vitro biology of Co (II), Ni (II), Cu (II) and Zinc (II) complexes of functionalized beta-diketone bearing energy buried potential antibacterial and antiviral O, O pharmacophore sites. Journal of Saudi Chemical Society. 2013. Vol. 17, no. 3, pp.269-276.
https://search.emarefa.net/detail/BIM-351668
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 276
Record ID
BIM-351668