Spectrophotometric determination of rantidine-HCl in pharmaceutical formulations

الملخص EN

Spectrophotometric methods were developed for the determination of rantidine-HCl in pharmaceutical tablets.

These methods were based on the reaction of DDQ and p-chloranil with rantidine-HCl, res ulting in the formation of an orange-red and purple colored products which are quantified spectrophotometrically at 460 and 540nm in DDQ and p-chloranil, respectively.

A graph of absorbance versus concentration show that Beer’s law is obeyed in a concentration ranges of 20-160 and (30-120)g/ml with molar absorptivities of 2.631 x 103 and 1.052 x 103l .mol-1-cm-1 for DDQ and p-chloranil, respectively.

The optimum conditions for color development are described and the proposed methods were applied s atisfactory to pharmaceutical preparations.