Relation of middle molecules levels and oxidative stress to erythropoietin requirements in high-flux versus low-flux hemodialysis
المؤلفون المشاركون
Abu Zayd, Ablah A.
al-Jawhari, Iman E.
Abu al-Suud, Nahlah A.
al-Wakil, Halah S.
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 24، العدد 5 (30 سبتمبر/أيلول 2013)، ص ص. 930-937، 8ص.
الناشر
تاريخ النشر
2013-09-30
دولة النشر
السعودية
عدد الصفحات
8
التخصصات الرئيسية
الموضوعات
الملخص EN
The objective of this study is to investigate the serum beta-2-microglobulin (B2MG) and advanced oxidation protein products (AOPP) as middle molecule uremic toxins and protein carbonyl (PCO) as oxidative stress marker in uremic patients undergoing high-flux versus low-flux hemodialysis (HD) and to correlate their levels to the erythropoietin requirements for those patients.
Twenty patients on chronic low-flux HD were recruited in the study.
At the start of the study, all patients underwent high-flux HD for eight weeks, followed by low-flux HD for two weeks as a washout period.
The patients were then subjected to another eight weeks of low-flux HD.
Blood samples were obtained at the beginning and at the end of the high-flux period and the low-flux period.
The mean erythropoietin dose for patients using high-flux HD was significantly lower than that for low-flux HD (P = 0.0062).
Post-high flux, the B2MG and PCO levels were significantly lower than the pre-high-flux levels (P = 0.026 and 0.0005, respectively), but no significant change was observed in AOPP (P = 0.68).
Post-low flux, the B2MG, AOPP and PCO were significantly higher than the pre-low-flux levels (P = 0.0002, 0.021 and <0.0001, respectively).
Post-low flux, the B2MG and PCO were significantly higher than the post-high-flux levels (P <0.0001), but no significant difference was observed in AOPP (P = 0.11).
High-flux HD results in reduction of some of the middle molecule toxins and PCO levels better than low-flux HD, and is associated with a better response to erythropoietin.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Wakil, Halah S.& Abu Zayd, Ablah A.& al-Jawhari, Iman E.& Abu al-Suud, Nahlah A.. 2013. Relation of middle molecules levels and oxidative stress to erythropoietin requirements in high-flux versus low-flux hemodialysis. Saudi Journal of Kidney Diseases and Transplantation،Vol. 24, no. 5, pp.930-937.
https://search.emarefa.net/detail/BIM-355779
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Wakil, Halah S.…[et al.]. Relation of middle molecules levels and oxidative stress to erythropoietin requirements in high-flux versus low-flux hemodialysis. Saudi Journal of Kidney Diseases and Transplantation Vol. 24, no. 5 (2013), pp.930-937.
https://search.emarefa.net/detail/BIM-355779
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Wakil, Halah S.& Abu Zayd, Ablah A.& al-Jawhari, Iman E.& Abu al-Suud, Nahlah A.. Relation of middle molecules levels and oxidative stress to erythropoietin requirements in high-flux versus low-flux hemodialysis. Saudi Journal of Kidney Diseases and Transplantation. 2013. Vol. 24, no. 5, pp.930-937.
https://search.emarefa.net/detail/BIM-355779
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 935-937
رقم السجل
BIM-355779
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر