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Relation of middle molecules levels and oxidative stress to erythropoietin requirements in high-flux versus low-flux hemodialysis
المؤلفون المشاركون
Abu Zayd, Ablah A.
al-Jawhari, Iman E.
Abu al-Suud, Nahlah A.
al-Wakil, Halah S.
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 24، العدد 5 (30 سبتمبر/أيلول 2013)، ص ص. 930-937، 8ص.
الناشر
تاريخ النشر
2013-09-30
دولة النشر
السعودية
عدد الصفحات
8
التخصصات الرئيسية
الموضوعات
الملخص EN
The objective of this study is to investigate the serum beta-2-microglobulin (B2MG) and advanced oxidation protein products (AOPP) as middle molecule uremic toxins and protein carbonyl (PCO) as oxidative stress marker in uremic patients undergoing high-flux versus low-flux hemodialysis (HD) and to correlate their levels to the erythropoietin requirements for those patients.
Twenty patients on chronic low-flux HD were recruited in the study.
At the start of the study, all patients underwent high-flux HD for eight weeks, followed by low-flux HD for two weeks as a washout period.
The patients were then subjected to another eight weeks of low-flux HD.
Blood samples were obtained at the beginning and at the end of the high-flux period and the low-flux period.
The mean erythropoietin dose for patients using high-flux HD was significantly lower than that for low-flux HD (P = 0.0062).
Post-high flux, the B2MG and PCO levels were significantly lower than the pre-high-flux levels (P = 0.026 and 0.0005, respectively), but no significant change was observed in AOPP (P = 0.68).
Post-low flux, the B2MG, AOPP and PCO were significantly higher than the pre-low-flux levels (P = 0.0002, 0.021 and <0.0001, respectively).
Post-low flux, the B2MG and PCO were significantly higher than the post-high-flux levels (P <0.0001), but no significant difference was observed in AOPP (P = 0.11).
High-flux HD results in reduction of some of the middle molecule toxins and PCO levels better than low-flux HD, and is associated with a better response to erythropoietin.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Wakil, Halah S.& Abu Zayd, Ablah A.& al-Jawhari, Iman E.& Abu al-Suud, Nahlah A.. 2013. Relation of middle molecules levels and oxidative stress to erythropoietin requirements in high-flux versus low-flux hemodialysis. Saudi Journal of Kidney Diseases and Transplantation،Vol. 24, no. 5, pp.930-937.
https://search.emarefa.net/detail/BIM-355779
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Wakil, Halah S.…[et al.]. Relation of middle molecules levels and oxidative stress to erythropoietin requirements in high-flux versus low-flux hemodialysis. Saudi Journal of Kidney Diseases and Transplantation Vol. 24, no. 5 (2013), pp.930-937.
https://search.emarefa.net/detail/BIM-355779
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Wakil, Halah S.& Abu Zayd, Ablah A.& al-Jawhari, Iman E.& Abu al-Suud, Nahlah A.. Relation of middle molecules levels and oxidative stress to erythropoietin requirements in high-flux versus low-flux hemodialysis. Saudi Journal of Kidney Diseases and Transplantation. 2013. Vol. 24, no. 5, pp.930-937.
https://search.emarefa.net/detail/BIM-355779
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 935-937
رقم السجل
BIM-355779
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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