Relation of middle molecules levels and oxidative stress to erythropoietin requirements in high-flux versus low-flux hemodialysis
Joint Authors
Abu Zayd, Ablah A.
al-Jawhari, Iman E.
Abu al-Suud, Nahlah A.
al-Wakil, Halah S.
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 24, Issue 5 (30 Sep. 2013), pp.930-937, 8 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2013-09-30
Country of Publication
Saudi Arabia
No. of Pages
8
Main Subjects
Topics
Abstract EN
The objective of this study is to investigate the serum beta-2-microglobulin (B2MG) and advanced oxidation protein products (AOPP) as middle molecule uremic toxins and protein carbonyl (PCO) as oxidative stress marker in uremic patients undergoing high-flux versus low-flux hemodialysis (HD) and to correlate their levels to the erythropoietin requirements for those patients.
Twenty patients on chronic low-flux HD were recruited in the study.
At the start of the study, all patients underwent high-flux HD for eight weeks, followed by low-flux HD for two weeks as a washout period.
The patients were then subjected to another eight weeks of low-flux HD.
Blood samples were obtained at the beginning and at the end of the high-flux period and the low-flux period.
The mean erythropoietin dose for patients using high-flux HD was significantly lower than that for low-flux HD (P = 0.0062).
Post-high flux, the B2MG and PCO levels were significantly lower than the pre-high-flux levels (P = 0.026 and 0.0005, respectively), but no significant change was observed in AOPP (P = 0.68).
Post-low flux, the B2MG, AOPP and PCO were significantly higher than the pre-low-flux levels (P = 0.0002, 0.021 and <0.0001, respectively).
Post-low flux, the B2MG and PCO were significantly higher than the post-high-flux levels (P <0.0001), but no significant difference was observed in AOPP (P = 0.11).
High-flux HD results in reduction of some of the middle molecule toxins and PCO levels better than low-flux HD, and is associated with a better response to erythropoietin.
American Psychological Association (APA)
al-Wakil, Halah S.& Abu Zayd, Ablah A.& al-Jawhari, Iman E.& Abu al-Suud, Nahlah A.. 2013. Relation of middle molecules levels and oxidative stress to erythropoietin requirements in high-flux versus low-flux hemodialysis. Saudi Journal of Kidney Diseases and Transplantation،Vol. 24, no. 5, pp.930-937.
https://search.emarefa.net/detail/BIM-355779
Modern Language Association (MLA)
al-Wakil, Halah S.…[et al.]. Relation of middle molecules levels and oxidative stress to erythropoietin requirements in high-flux versus low-flux hemodialysis. Saudi Journal of Kidney Diseases and Transplantation Vol. 24, no. 5 (2013), pp.930-937.
https://search.emarefa.net/detail/BIM-355779
American Medical Association (AMA)
al-Wakil, Halah S.& Abu Zayd, Ablah A.& al-Jawhari, Iman E.& Abu al-Suud, Nahlah A.. Relation of middle molecules levels and oxidative stress to erythropoietin requirements in high-flux versus low-flux hemodialysis. Saudi Journal of Kidney Diseases and Transplantation. 2013. Vol. 24, no. 5, pp.930-937.
https://search.emarefa.net/detail/BIM-355779
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 935-937
Record ID
BIM-355779