Galectin-3 immunostaining in cytological and histopathological diagnosis of thyroid lesions
المؤلفون المشاركون
Ayyad, Hiyam A.
Asad, Nansi Y.
al-Qasid, Ahmad M.
al-Judi, Shirin F.
Qandil, Muna A.
المصدر
Journal of the Egyptian National Cancer Institute
العدد
المجلد 20، العدد 1 (31 مارس/آذار 2008)، ص ص. 36-46، 11ص.
الناشر
جامعة القاهرة المعهد القومي للأورام
تاريخ النشر
2008-03-31
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الموضوعات
الملخص EN
Background: Galectin-3 is a human lectin linked to malignant transformation in different organs including thyroid gland.
We aimed to evaluate the diagnostic role of galectin-3 in differentiating benign from malignant thyroid lesions in cytological and histological samples.
Material and Methods: This study included a total of 79 cases; 19 multinodular goiter (MNG), 19 follicular adenoma (FA), 13 follicular carcinoma (FTC) and 28 papillary carcinoma (PTC).
Galectin-3 immunostaining was applied on histological sections from all the cases (retrospective analysis) as well as for the available preoperative FNAC (28 cases) (prospective analysis).
Results: Retrospective analysis: The positivity percentage of galectin-3 was 10.5%, 92.3%, 93% for nonmalignant, FTC and PTC respectively.
According to H score, glaectin-3 immunostaining was significantly lowered in FA) 1±2.8 as compared to papillary (158.5±88.6) and follicular carcinoma (150±83.9) (p>0.0001).
However, there was no statistically significant difference between FTC and PTC (p=0.56) or between classic and follicular variants of PTC (p=0.51).
Sensitivity, specificity, positive and negative predictive values for galectin-3 staining were 93%, 89.5%, 90.5% and 92% respectively.
Prospective analysis: There were five benign, six malignant and 17 indeterminate cytology cases.
Galectin-3 immunostaining was able to detect the benign nature of 11/17 indeterminate cytology.
Combination of standard cytological evaluation with galectin-3 immunostaining markedly improved sensitivity (71% versus 85%), specificity (75% versus 94%), positive predictive value (83% versus 92%) negative predictive value (60% versus 87.5%) and diagnostic accuracy (72% versus 90%).
Conclusion: We suggest Galectin-3 as a supplementary immunostaining in histological diagnosis of difficult thyroid follicular lesions and in preoperative evaluation Journal of the Egyptian Nat.
Cancer Inst., Vol.
20, No.
1, March: 36-46, 2008 Galectin-3 Immunostaining in Cytological and Histopathological Diagnosis of Thyroid Lesions HAYAM A.
AIAD, M.D.*; MONA A.
KANDIL, M.D.*; NANCY Y.
ASAAD, M.D.*; AHMAD M.
EL-KASED, M.D.** and SHEREN F.
EL-GODAY, MS.c.* The Departments of Pathology* and General Surgery**, Faculty of Medicine, Menoufiya University.
36 of indeterminate thyroid cytology to avoid unnecessary aggressive surgical interference in benign lesions.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ayyad, Hiyam A.& Qandil, Muna A.& Asad, Nansi Y.& al-Qasid, Ahmad M.& al-Judi, Shirin F.. 2008. Galectin-3 immunostaining in cytological and histopathological diagnosis of thyroid lesions. Journal of the Egyptian National Cancer Institute،Vol. 20, no. 1, pp.36-46.
https://search.emarefa.net/detail/BIM-355782
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ayyad, Hiyam A.…[et al.]. Galectin-3 immunostaining in cytological and histopathological diagnosis of thyroid lesions. Journal of the Egyptian National Cancer Institute Vol. 20, no. 1 (Mar. 2008), pp.36-46.
https://search.emarefa.net/detail/BIM-355782
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ayyad, Hiyam A.& Qandil, Muna A.& Asad, Nansi Y.& al-Qasid, Ahmad M.& al-Judi, Shirin F.. Galectin-3 immunostaining in cytological and histopathological diagnosis of thyroid lesions. Journal of the Egyptian National Cancer Institute. 2008. Vol. 20, no. 1, pp.36-46.
https://search.emarefa.net/detail/BIM-355782
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 44-46
رقم السجل
BIM-355782
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر