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Galectin-3 immunostaining in cytological and histopathological diagnosis of thyroid lesions
Joint Authors
Ayyad, Hiyam A.
Asad, Nansi Y.
al-Qasid, Ahmad M.
al-Judi, Shirin F.
Qandil, Muna A.
Source
Journal of the Egyptian National Cancer Institute
Issue
Vol. 20, Issue 1 (31 Mar. 2008), pp.36-46, 11 p.
Publisher
Cairo University National Cancer Institute
Publication Date
2008-03-31
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Topics
Abstract EN
Background: Galectin-3 is a human lectin linked to malignant transformation in different organs including thyroid gland.
We aimed to evaluate the diagnostic role of galectin-3 in differentiating benign from malignant thyroid lesions in cytological and histological samples.
Material and Methods: This study included a total of 79 cases; 19 multinodular goiter (MNG), 19 follicular adenoma (FA), 13 follicular carcinoma (FTC) and 28 papillary carcinoma (PTC).
Galectin-3 immunostaining was applied on histological sections from all the cases (retrospective analysis) as well as for the available preoperative FNAC (28 cases) (prospective analysis).
Results: Retrospective analysis: The positivity percentage of galectin-3 was 10.5%, 92.3%, 93% for nonmalignant, FTC and PTC respectively.
According to H score, glaectin-3 immunostaining was significantly lowered in FA) 1±2.8 as compared to papillary (158.5±88.6) and follicular carcinoma (150±83.9) (p>0.0001).
However, there was no statistically significant difference between FTC and PTC (p=0.56) or between classic and follicular variants of PTC (p=0.51).
Sensitivity, specificity, positive and negative predictive values for galectin-3 staining were 93%, 89.5%, 90.5% and 92% respectively.
Prospective analysis: There were five benign, six malignant and 17 indeterminate cytology cases.
Galectin-3 immunostaining was able to detect the benign nature of 11/17 indeterminate cytology.
Combination of standard cytological evaluation with galectin-3 immunostaining markedly improved sensitivity (71% versus 85%), specificity (75% versus 94%), positive predictive value (83% versus 92%) negative predictive value (60% versus 87.5%) and diagnostic accuracy (72% versus 90%).
Conclusion: We suggest Galectin-3 as a supplementary immunostaining in histological diagnosis of difficult thyroid follicular lesions and in preoperative evaluation Journal of the Egyptian Nat.
Cancer Inst., Vol.
20, No.
1, March: 36-46, 2008 Galectin-3 Immunostaining in Cytological and Histopathological Diagnosis of Thyroid Lesions HAYAM A.
AIAD, M.D.*; MONA A.
KANDIL, M.D.*; NANCY Y.
ASAAD, M.D.*; AHMAD M.
EL-KASED, M.D.** and SHEREN F.
EL-GODAY, MS.c.* The Departments of Pathology* and General Surgery**, Faculty of Medicine, Menoufiya University.
36 of indeterminate thyroid cytology to avoid unnecessary aggressive surgical interference in benign lesions.
American Psychological Association (APA)
Ayyad, Hiyam A.& Qandil, Muna A.& Asad, Nansi Y.& al-Qasid, Ahmad M.& al-Judi, Shirin F.. 2008. Galectin-3 immunostaining in cytological and histopathological diagnosis of thyroid lesions. Journal of the Egyptian National Cancer Institute،Vol. 20, no. 1, pp.36-46.
https://search.emarefa.net/detail/BIM-355782
Modern Language Association (MLA)
Ayyad, Hiyam A.…[et al.]. Galectin-3 immunostaining in cytological and histopathological diagnosis of thyroid lesions. Journal of the Egyptian National Cancer Institute Vol. 20, no. 1 (Mar. 2008), pp.36-46.
https://search.emarefa.net/detail/BIM-355782
American Medical Association (AMA)
Ayyad, Hiyam A.& Qandil, Muna A.& Asad, Nansi Y.& al-Qasid, Ahmad M.& al-Judi, Shirin F.. Galectin-3 immunostaining in cytological and histopathological diagnosis of thyroid lesions. Journal of the Egyptian National Cancer Institute. 2008. Vol. 20, no. 1, pp.36-46.
https://search.emarefa.net/detail/BIM-355782
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 44-46
Record ID
BIM-355782