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T (14; 18) is not associated with mixed cryoglobulinemia or with clonal b cell expansion in Egyptian patients with hepatitis C virus infection
المؤلفون المشاركون
Umar, Nabil A.
Hasan, Zaynab K.
Abbas, Umaymah M.
المصدر
Journal of the Egyptian National Cancer Institute
العدد
المجلد 20، العدد 2 (30 يونيو/حزيران 2008)، ص ص. 149-157، 9ص.
الناشر
جامعة القاهرة المعهد القومي للأورام
تاريخ النشر
2008-06-30
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الموضوعات
الملخص EN
Background/Aim : The mechanisms of B-cell lymphoproliferative disorders in chronic hepatitis C virus (HCV) infection are unclear.
An increased prevalence of circulating monoclonal B-cells and t(14;18) has been reported.
Geographic heterogeneity of prevalence of t(14;18) has been shown to exist.
We investigated the prevalence of t(14;18) and B-cell clonality as possible mechanisms of lymphomagenesis in chronic HCV patients, in whom cryoglobulinemia status was previously detected.
Methods: A cohort of 111 patients was studied, including 87 patients with chronic HCV disease (18 cryoglobulinemic and 69 non- cryoglobulinemic); 24 HCVnegative, cryoglobulin negative patients with other nonimmune chronic liver diseases were enrolled as controls.
The t(14;18) and IgH rearrangement (as a marker of Bcell clonality) were detected by the polymerase chain reaction.
Results: t(14;18) was detected in 27.6% of HCV patients and in none of the controls.
Detection rates were comparable in both cryoglobulin-positive and negative groups (22.2% and 29%, respectively), p=0.769.
IgH rearrangement was detected in 39.1% of HCV patients and in none of the controls.
The cryoglobulin-positive group showed significantly higher prevalence of IgH rearrangement compared to the cryoglobulin-negative group (61.1% and 33.3%, respectively), p=0.03, OR=3.13 and 95% CI=1.07-9.17.
t(14;18) and monoclonal IgH rearrangement detection rates were not associated with each other, p=0.467.
Conclusion: t(14;18) is uncommon in HCV-mixed cryogoblulinemia Egyptian patients; it does not seem to play a role in HCV-associated MC and lymphomagenesis in our geographical area.
HCV may play a role in mixed cryogoblulinemia and lymphomagenesis, probably by inducing clonal B-cell expansions.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abbas, Umaymah M.& Umar, Nabil A.& Hasan, Zaynab K.. 2008. T (14; 18) is not associated with mixed cryoglobulinemia or with clonal b cell expansion in Egyptian patients with hepatitis C virus infection. Journal of the Egyptian National Cancer Institute،Vol. 20, no. 2, pp.149-157.
https://search.emarefa.net/detail/BIM-355837
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abbas, Umaymah M.…[et al.]. T (14; 18) is not associated with mixed cryoglobulinemia or with clonal b cell expansion in Egyptian patients with hepatitis C virus infection. Journal of the Egyptian National Cancer Institute Vol. 20, no. 2 (Jun. 2008), pp.149-157.
https://search.emarefa.net/detail/BIM-355837
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abbas, Umaymah M.& Umar, Nabil A.& Hasan, Zaynab K.. T (14; 18) is not associated with mixed cryoglobulinemia or with clonal b cell expansion in Egyptian patients with hepatitis C virus infection. Journal of the Egyptian National Cancer Institute. 2008. Vol. 20, no. 2, pp.149-157.
https://search.emarefa.net/detail/BIM-355837
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 155-157
رقم السجل
BIM-355837
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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