T (14; 18) is not associated with mixed cryoglobulinemia or with clonal b cell expansion in Egyptian patients with hepatitis C virus infection
Joint Authors
Umar, Nabil A.
Hasan, Zaynab K.
Abbas, Umaymah M.
Source
Journal of the Egyptian National Cancer Institute
Issue
Vol. 20, Issue 2 (30 Jun. 2008), pp.149-157, 9 p.
Publisher
Cairo University National Cancer Institute
Publication Date
2008-06-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Topics
Abstract EN
Background/Aim : The mechanisms of B-cell lymphoproliferative disorders in chronic hepatitis C virus (HCV) infection are unclear.
An increased prevalence of circulating monoclonal B-cells and t(14;18) has been reported.
Geographic heterogeneity of prevalence of t(14;18) has been shown to exist.
We investigated the prevalence of t(14;18) and B-cell clonality as possible mechanisms of lymphomagenesis in chronic HCV patients, in whom cryoglobulinemia status was previously detected.
Methods: A cohort of 111 patients was studied, including 87 patients with chronic HCV disease (18 cryoglobulinemic and 69 non- cryoglobulinemic); 24 HCVnegative, cryoglobulin negative patients with other nonimmune chronic liver diseases were enrolled as controls.
The t(14;18) and IgH rearrangement (as a marker of Bcell clonality) were detected by the polymerase chain reaction.
Results: t(14;18) was detected in 27.6% of HCV patients and in none of the controls.
Detection rates were comparable in both cryoglobulin-positive and negative groups (22.2% and 29%, respectively), p=0.769.
IgH rearrangement was detected in 39.1% of HCV patients and in none of the controls.
The cryoglobulin-positive group showed significantly higher prevalence of IgH rearrangement compared to the cryoglobulin-negative group (61.1% and 33.3%, respectively), p=0.03, OR=3.13 and 95% CI=1.07-9.17.
t(14;18) and monoclonal IgH rearrangement detection rates were not associated with each other, p=0.467.
Conclusion: t(14;18) is uncommon in HCV-mixed cryogoblulinemia Egyptian patients; it does not seem to play a role in HCV-associated MC and lymphomagenesis in our geographical area.
HCV may play a role in mixed cryogoblulinemia and lymphomagenesis, probably by inducing clonal B-cell expansions.
American Psychological Association (APA)
Abbas, Umaymah M.& Umar, Nabil A.& Hasan, Zaynab K.. 2008. T (14; 18) is not associated with mixed cryoglobulinemia or with clonal b cell expansion in Egyptian patients with hepatitis C virus infection. Journal of the Egyptian National Cancer Institute،Vol. 20, no. 2, pp.149-157.
https://search.emarefa.net/detail/BIM-355837
Modern Language Association (MLA)
Abbas, Umaymah M.…[et al.]. T (14; 18) is not associated with mixed cryoglobulinemia or with clonal b cell expansion in Egyptian patients with hepatitis C virus infection. Journal of the Egyptian National Cancer Institute Vol. 20, no. 2 (Jun. 2008), pp.149-157.
https://search.emarefa.net/detail/BIM-355837
American Medical Association (AMA)
Abbas, Umaymah M.& Umar, Nabil A.& Hasan, Zaynab K.. T (14; 18) is not associated with mixed cryoglobulinemia or with clonal b cell expansion in Egyptian patients with hepatitis C virus infection. Journal of the Egyptian National Cancer Institute. 2008. Vol. 20, no. 2, pp.149-157.
https://search.emarefa.net/detail/BIM-355837
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 155-157
Record ID
BIM-355837