Soluble mesothelin-related protein in malignant pleural mesothelioma
المؤلفون المشاركون
Jafar, Rabab
Abd al-Salam, Ibrahim
al-Jundi, Sad
Ashmawi, Abir
al-Attar, Inas
Khurshid, Ula
Azim, Hatim A.
المصدر
Journal of the Egyptian National Cancer Institute
العدد
المجلد 20، العدد 3 (30 سبتمبر/أيلول 2008)، ص ص. 224-229، 6ص.
الناشر
جامعة القاهرة المعهد القومي للأورام
تاريخ النشر
2008-09-30
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الموضوعات
الملخص EN
Background and Purpose : Building-up evidence suggests that soluble mesothelinrelated protein (SMRP) carries a diagnostic and a prognostic value in malignant pleural mesothelioma (MPM).
Egypt suffers endemic asbestosis and thus this study was conducted to evaluate the sensitivity and specificity of SMRP in patients with MPM and to correlate this marker with known clinicopathological prognostic factors.
Material and Methods : During the period from January 2006 till March 2008, Serum samples were obtained from MPM patients presenting to the Egyptian National Cancer Institute, Cairo University.
Serum samples were provided from patients with breast cancer and from healthy individuals to function as controls.
The SMRP was assayed using the ELISA technique and correlations were made with different clinico-pathological prognostic parameters.
Results : 83 patients (50 MPM and 33 breast cancer) as well as 22 healthy individuals were enrolled in this study.
Serum SMRP levels were not different between patients with breast cancer and healthy controls (p>0.05).
However, there was a significant difference between MPM patients and the other two groups (p<0.0001).
ROC analysis showed an AUC=0.765 for differentiating between the controls and MPM with a best statistical cut-off of 7.22nM/L (sensitivity=66%, specificity=70.9%).
The mean SMRP concentrations were significantly higher in patients with advanced disease (p=0.038), poor performance status (p=0.017) and high alkaline phosphatase (p=0.015).
The mean SMRP concentrations were also higher in males, elderly patients, asbestos-exposed patients, epithelioid subtypes and patients with high platelet and leucocytic counts.
However, these differences did not reach statistical significance.
Conclusions : This study confirms that SMRP is of considerable sensitivity and specificity in Egyptian patients with MPM.
Higher levels are frequently seen in patients with high tumor burden, which could be helpful in monitoring response to therapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Azim, Hatim A.& Jafar, Rabab& Abd al-Salam, Ibrahim& al-Jundi, Sad& al-Attar, Inas& Ashmawi, Abir…[et al.]. 2008. Soluble mesothelin-related protein in malignant pleural mesothelioma. Journal of the Egyptian National Cancer Institute،Vol. 20, no. 3, pp.224-229.
https://search.emarefa.net/detail/BIM-355875
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Azim, Hatim A.…[et al.]. Soluble mesothelin-related protein in malignant pleural mesothelioma. Journal of the Egyptian National Cancer Institute Vol. 20, no. 3 (Sep. 2008), pp.224-229.
https://search.emarefa.net/detail/BIM-355875
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Azim, Hatim A.& Jafar, Rabab& Abd al-Salam, Ibrahim& al-Jundi, Sad& al-Attar, Inas& Ashmawi, Abir…[et al.]. Soluble mesothelin-related protein in malignant pleural mesothelioma. Journal of the Egyptian National Cancer Institute. 2008. Vol. 20, no. 3, pp.224-229.
https://search.emarefa.net/detail/BIM-355875
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 228-229
رقم السجل
BIM-355875
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر