Soluble mesothelin-related protein in malignant pleural mesothelioma
Joint Authors
Jafar, Rabab
Abd al-Salam, Ibrahim
al-Jundi, Sad
Ashmawi, Abir
al-Attar, Inas
Khurshid, Ula
Azim, Hatim A.
Source
Journal of the Egyptian National Cancer Institute
Issue
Vol. 20, Issue 3 (30 Sep. 2008), pp.224-229, 6 p.
Publisher
Cairo University National Cancer Institute
Publication Date
2008-09-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Topics
Abstract EN
Background and Purpose : Building-up evidence suggests that soluble mesothelinrelated protein (SMRP) carries a diagnostic and a prognostic value in malignant pleural mesothelioma (MPM).
Egypt suffers endemic asbestosis and thus this study was conducted to evaluate the sensitivity and specificity of SMRP in patients with MPM and to correlate this marker with known clinicopathological prognostic factors.
Material and Methods : During the period from January 2006 till March 2008, Serum samples were obtained from MPM patients presenting to the Egyptian National Cancer Institute, Cairo University.
Serum samples were provided from patients with breast cancer and from healthy individuals to function as controls.
The SMRP was assayed using the ELISA technique and correlations were made with different clinico-pathological prognostic parameters.
Results : 83 patients (50 MPM and 33 breast cancer) as well as 22 healthy individuals were enrolled in this study.
Serum SMRP levels were not different between patients with breast cancer and healthy controls (p>0.05).
However, there was a significant difference between MPM patients and the other two groups (p<0.0001).
ROC analysis showed an AUC=0.765 for differentiating between the controls and MPM with a best statistical cut-off of 7.22nM/L (sensitivity=66%, specificity=70.9%).
The mean SMRP concentrations were significantly higher in patients with advanced disease (p=0.038), poor performance status (p=0.017) and high alkaline phosphatase (p=0.015).
The mean SMRP concentrations were also higher in males, elderly patients, asbestos-exposed patients, epithelioid subtypes and patients with high platelet and leucocytic counts.
However, these differences did not reach statistical significance.
Conclusions : This study confirms that SMRP is of considerable sensitivity and specificity in Egyptian patients with MPM.
Higher levels are frequently seen in patients with high tumor burden, which could be helpful in monitoring response to therapy.
American Psychological Association (APA)
Azim, Hatim A.& Jafar, Rabab& Abd al-Salam, Ibrahim& al-Jundi, Sad& al-Attar, Inas& Ashmawi, Abir…[et al.]. 2008. Soluble mesothelin-related protein in malignant pleural mesothelioma. Journal of the Egyptian National Cancer Institute،Vol. 20, no. 3, pp.224-229.
https://search.emarefa.net/detail/BIM-355875
Modern Language Association (MLA)
Azim, Hatim A.…[et al.]. Soluble mesothelin-related protein in malignant pleural mesothelioma. Journal of the Egyptian National Cancer Institute Vol. 20, no. 3 (Sep. 2008), pp.224-229.
https://search.emarefa.net/detail/BIM-355875
American Medical Association (AMA)
Azim, Hatim A.& Jafar, Rabab& Abd al-Salam, Ibrahim& al-Jundi, Sad& al-Attar, Inas& Ashmawi, Abir…[et al.]. Soluble mesothelin-related protein in malignant pleural mesothelioma. Journal of the Egyptian National Cancer Institute. 2008. Vol. 20, no. 3, pp.224-229.
https://search.emarefa.net/detail/BIM-355875
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 228-229
Record ID
BIM-355875