Simple and convenient procedure for the synthesis of 2-(3-(tert-Butoxycarbonylamino)‎ propyl)‎-5-methylthiophenes

الملخص EN

2-(3-(tert-Butoxycarbonylamino) propyl)-5-methylthiophene and its 4-deuterio derivative have been synthesized by a simple and convenient method in a six step sequence from 2-methylthiophene.

The final step involved bromine-lithium exchange on 4-bromo-2-(3-(tert-butoxycarbonylamino)propyl) -5- methylthiophene at low temperature in anhydrous tetrahydrofuran followed by treatment with water or D2O.