Simple and convenient procedure for the synthesis of 2-(3-(tert-Butoxycarbonylamino) propyl)-5-methylthiophenes
Joint Authors
Balakit, Asim A.
al-Hiti, Jamal A.
Smith, Keith
Source
Iraqi National Journal of Chemistry
Issue
Vol. 2013, Issue 52 (31 Dec. 2013), pp.466-476, 11 p.
Publisher
University of Babylon College of Sciences
Publication Date
2013-12-31
Country of Publication
Iraq
No. of Pages
11
Main Subjects
Abstract AR
تتضمن هذه الدراسة تحضير 2-(-3-ثلاثي-بيوتوكسي كاربونيل امينو) بروبيل)-5-مثيل ثايوفين و مشتقه المعوض بالديوتريوم في الموقع 4 بطريقة بسيطة و عملية بستة خطوات و ابتداءا من 2-مثيل ثاويوفين.
الخطوة الأخيرة في هذا التحضير تضمنت تفاعل استبدال البروم بالليثيوم في درجة حرارة منخفضة باستخدام التتراهايدروفيوران الجاف كمذيب يعقبه معاملة مزيج التفاعل بالماء و الD2O.
Abstract EN
2-(3-(tert-Butoxycarbonylamino) propyl)-5-methylthiophene and its 4-deuterio derivative have been synthesized by a simple and convenient method in a six step sequence from 2-methylthiophene.
The final step involved bromine-lithium exchange on 4-bromo-2-(3-(tert-butoxycarbonylamino)propyl) -5- methylthiophene at low temperature in anhydrous tetrahydrofuran followed by treatment with water or D2O.
American Psychological Association (APA)
Balakit, Asim A.& al-Hiti, Jamal A.& Smith, Keith. 2013. Simple and convenient procedure for the synthesis of 2-(3-(tert-Butoxycarbonylamino) propyl)-5-methylthiophenes. Iraqi National Journal of Chemistry،Vol. 2013, no. 52, pp.466-476.
https://search.emarefa.net/detail/BIM-357591
Modern Language Association (MLA)
Balakit, Asim A.…[et al.]. Simple and convenient procedure for the synthesis of 2-(3-(tert-Butoxycarbonylamino) propyl)-5-methylthiophenes. Iraqi National Journal of Chemistry No. 52 (2013), pp.466-476.
https://search.emarefa.net/detail/BIM-357591
American Medical Association (AMA)
Balakit, Asim A.& al-Hiti, Jamal A.& Smith, Keith. Simple and convenient procedure for the synthesis of 2-(3-(tert-Butoxycarbonylamino) propyl)-5-methylthiophenes. Iraqi National Journal of Chemistry. 2013. Vol. 2013, no. 52, pp.466-476.
https://search.emarefa.net/detail/BIM-357591
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 476
Record ID
BIM-357591
