Antioxidative,antimicrobial and cytotoxic effects of the phenolics of leea indica leaf extract
المؤلفون المشاركون
Rahman, Attar
Bin Umran, Talhat
Islam, Shahid
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 20، العدد 3 (31 يوليو/تموز 2013)، ص ص. 213-225، 13ص.
الناشر
تاريخ النشر
2013-07-31
دولة النشر
السعودية
عدد الصفحات
13
التخصصات الرئيسية
الموضوعات
الملخص EN
This study investigated the phytochemical, antioxidative, antimicrobial and cytotoxic effects of Leea indica leaf ethanol extract.
Phytochemical values namely total phenolic and flavonoid contents, total antioxidant capacity, DPPH radical scavenging effect, FeCl3 reducing power, DMSO superoxide scavenging effect and Iron chelating effects were studied by established methods.
Antibacterial, antifungal and cytotoxic effects were screened by disk diffusion technique, food poison technique and brine shrimp bioassay, respectively.
Results showed the total phenolic content 24.00 ±0.81 g GAE / 100 g, total flavonoid content 194.68± 2.43 g quercetin / 100 g and total antioxidant capacity 106.61 ± 1.84 g AA / 100 g dry extract.
Significant (P < 0.05) IC50 values compared to respective standards were recorded in DPPH radical scavenging (139.83 ± 1.40 lg / ml), FeCl3 reduction (16.48 ± 0.64 lg / ml), DMSO superoxide scavenging (676.08 ± 5.80 lg / ml) and Iron chelating (519.33 ± 16.96 lg / ml) methods.
In antibacterial screening, the extract showed significant (P < 0.05) zone of inhibitions compared to positive controls Ampicillin and Tetracycline against Gram positive Bacillus subtilis, Bacillus cereus, Bacillus megaterium, and Staphylococcus aureus and Gram negative Salmonella typhi, Salmonella paratyphi, Pseudomonas aeroginosa, Shigella dysenteriae, Vibrio cholerae, and Escherichia coli.
Significant minimum inhibitory concentrations compared to tetracycline were obtained against the above organisms.
In antifungal assay, the extract inhibited the growth of Aspergillus flavus, Candida albicans and Fusarium equisetii by 38.09 ± 0.59, 22.58 ±2.22, and 22.58 ± 2.22 %, respectively.
The extract showed a significant LC50 value compared to vincristine sulfate in cytotoxic assay.
The results evidenced the potential.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rahman, Attar& Bin Umran, Talhat& Islam, Shahid. 2013. Antioxidative,antimicrobial and cytotoxic effects of the phenolics of leea indica leaf extract. Saudi Journal of Biological Sciences،Vol. 20, no. 3, pp.213-225.
https://search.emarefa.net/detail/BIM-358248
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rahman, Attar…[et al.]. Antioxidative,antimicrobial and cytotoxic effects of the phenolics of leea indica leaf extract. Saudi Journal of Biological Sciences Vol. 20, no. 3 (Jul. 2013), pp.213-225.
https://search.emarefa.net/detail/BIM-358248
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rahman, Attar& Bin Umran, Talhat& Islam, Shahid. Antioxidative,antimicrobial and cytotoxic effects of the phenolics of leea indica leaf extract. Saudi Journal of Biological Sciences. 2013. Vol. 20, no. 3, pp.213-225.
https://search.emarefa.net/detail/BIM-358248
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 223-225
رقم السجل
BIM-358248
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر