Markers of neural degeneration and regeneration in Down syndrome patients
المؤلفون المشاركون
Abd al-Majid, Iman Ihsan
Abd al-Salam, Ikram
Abd al-Latif, Duaa M.
Kurraa, Suhayr
Ismail, Amal
المصدر
The Egyptian Journal of Medical Human Genetics
العدد
المجلد 14، العدد 1 (31 يناير/كانون الثاني 2013)، ص ص. 49-53، 5ص.
الناشر
الجمعية المصرية للأمراض الوراثية
تاريخ النشر
2013-01-31
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الموضوعات
الملخص EN
On the trisomy Down syndrome Critical Region (DSCR1) is located the APP gene, which accelerates amyloid peptide protein (APP) expression leading to cerebral accumulation of APP-derived amyloid-beta peptides (Ab) and age-dependent cognitive sequelae.
Also DSCR1 attenuates endothelial cell proliferation and angiogenesis required for tissue repair.
The aim of the present work is to determine markers of neural degeneration and regeneration in the blood of young and adolescent Down syndrome (DS) patients as well as controls.
Markers of regeneration were measured in terms of circulating mononuclear cells expressing Nestin and CD34, while markers of degeneration were measured in terms of plasma Ab42 and advanced glycation end products receptors (RAGES).
Results showed a significant increase in plasma Ab42 (20 ± 5.1 vs.
11.9 ± 3.4) and RAGES leucocytes mRNA relative expression (1.9 ± 0.2 vs.
1.1 ± 0.6) in adolescent DS patients compared to young DS.
Both parameters were also significantly increased in DS compared to controls : Ab42 (15.4 ± 5.9 vs.
12.
3 ± 4.5) ; RAGES (1.4 ± 0.5 vs.
0.7 ± 0.2).
Nestin (5.2 ± 1.4 vs.
6.3 ± 0.6) and CD34 (52 ± 2.5 vs.
53 ± 4.7) were non-significantly lower in adolescent DS patients compared to young DS, but significantly lower in DS patients compared to controls : Nestin (6.3 ± 1.5 vs.
9 ± 4.4) ; CD34 (54 ± 3.4 vs.
60 ± 4.8).
The significant decrease in the number of mononuclear cells bearing Nestin and CD34 markers accompanied by a significant increase in Ab42 and RAGES indicate that degeneration in DS is an ongoing process, which is not counterbalanced by the regenerative mechanism.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abd al-Majid, Iman Ihsan& Abd al-Salam, Ikram& Abd al-Latif, Duaa M.& Kurraa, Suhayr& Ismail, Amal. 2013. Markers of neural degeneration and regeneration in Down syndrome patients. The Egyptian Journal of Medical Human Genetics،Vol. 14, no. 1, pp.49-53.
https://search.emarefa.net/detail/BIM-358455
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kurraa, Suhayr…[et al.]. Markers of neural degeneration and regeneration in Down syndrome patients. The Egyptian Journal of Medical Human Genetics Vol. 14, no. 1 (Jan. 2013), pp.49-53.
https://search.emarefa.net/detail/BIM-358455
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abd al-Majid, Iman Ihsan& Abd al-Salam, Ikram& Abd al-Latif, Duaa M.& Kurraa, Suhayr& Ismail, Amal. Markers of neural degeneration and regeneration in Down syndrome patients. The Egyptian Journal of Medical Human Genetics. 2013. Vol. 14, no. 1, pp.49-53.
https://search.emarefa.net/detail/BIM-358455
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 52-53
رقم السجل
BIM-358455
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر